4.0
Summary
| Name |  ANXA2View Modifications |
| Full Name | Annexin A2 |
| Synonyms | Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein IV, PAP-IV, Protein I, p36 | ANX2, ANX2L4, CAL1H, LPC2D |
| Primary ID | P07355 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCB |
phosphorylation
|
ANXA2 | 0.332 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PRKCA |
phosphorylation
|
ANXA2 | 0.356 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC | up-regulates 
phosphorylation
|
ANXA2 | 0.549 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | YES1 | up-regulates activity
phosphorylation
|
ANXA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UBAP2 | down-regulates quantity 
ubiquitination
|
ANXA2 | 0.343 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBLL1 | down-regulates quantity by destabilization
ubiquitination
|
ANXA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |