| + |
YES1 | up-regulates activity 
phosphorylation
|
GLO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276185 |
Tyr136 |
GIAVPDVySACKRFE |
in vitro |
|
| pmid |
sentence |
| 34838714 |
We show that Glo1 activity is promoted by phosphorylation on Tyrosine 136 via multiple kinases. Glo1 Y136 is phosphorylated by multiple different kinases including all members of the Src family. Depletion of multiple different kinases led to a partial reduction in Glo1(Y136) phosphorylation. These included members of the Src family (Src, Yes1, FGR, and the related Abl1), and of the FAK, EPHA, FGFR, and VEGFR families (Figure 2B), suggesting phosphorylation of Glo1 on Y136 by multiple different kinases. In vitro kinase assays revealed that all the members of the Src family, as well as Epha5 and VEGFR3, can efficiently phosphorylate recombinant Glo1 on Y136 (Figure 2C–D). |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
YES1 | down-regulates 
phosphorylation
|
CDK4 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178624 |
Tyr17 |
AEIGVGAyGTVYKAR |
Homo sapiens |
|
| pmid |
sentence |
| 18479465 |
We purified tyrosine 17 kinases from hela cells and found that the src family non-receptor tyrosine kinase c-yes contributes a large fraction of the tyrosine 17 kinase activity in hela lysatesthis site is equivalent to tyrosine 15 of cyclin dependent kinase 1, which undergoes inhibitory phosphorylation by wee1 and myt1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YES1 | up-regulates activity
phosphorylation
|
WBP2 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273581 |
Tyr192 |
MMDGAMGyVQPPPPP |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21642474 |
Using dominant-negative, constitutively active mutants, RNAi, and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases.We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity, putatively by blocking nuclear entry of WBP2 and its interaction with ERα. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273582 |
Tyr231 |
AEAAASAyYNPGNPH |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21642474 |
Using dominant-negative, constitutively active mutants, RNAi, and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases.We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity, putatively by blocking nuclear entry of WBP2 and its interaction with ERα. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YES1 | up-regulates activity
phosphorylation
|
WWTR1 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277654 |
Tyr305 |
PFLNGGPyHSREQST |
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 35041461 |
Yes directly phosphorylates YAP and TAZ, resulting in their increased nuclear localization and transcriptional activity.Analysis by mass spectrometry identified Tyr391 and Tyr407 as the two phosphorylation sites of YAP, whereas Tyr305 was the sole phosphorylated residue of TAZ (Fig. 5F and fig. S4, A to C). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YES1 | up-regulates activity
phosphorylation
|
YAP1 |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277652 |
Tyr391 |
PFLNSGTyHSRDEST |
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 35041461 |
Yes directly phosphorylates YAP and TAZ, resulting in their increased nuclear localization and transcriptional activity.Analysis by mass spectrometry identified Tyr391 and Tyr407 as the two phosphorylation sites of YAP, whereas Tyr305 was the sole phosphorylated residue of TAZ (Fig. 5F and fig. S4, A to C). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277653 |
Tyr407 |
SGLSMSSySVPRTPD |
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 35041461 |
Yes directly phosphorylates YAP and TAZ, resulting in their increased nuclear localization and transcriptional activity.Analysis by mass spectrometry identified Tyr391 and Tyr407 as the two phosphorylation sites of YAP, whereas Tyr305 was the sole phosphorylated residue of TAZ (Fig. 5F and fig. S4, A to C). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AXL | up-regulates activity
phosphorylation
|
YES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277555 |
Tyr426 |
RLIEDNEyTARQGAK |
Homo sapiens |
AGS Cell |
| pmid |
sentence |
| 33941853 |
Here, we show that EphA2, YES1, and ANXA2 form a signal axis, in which YES1 activated by EphA2 phosphorylates ANXA2 at Tyr24 site, leading to ANXA2 activation and increased ANXA2 nuclear distribution in gastric cancer (GC) cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EPHA2 | up-regulates activity
phosphorylation
|
YES1 |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277556 |
Tyr426 |
RLIEDNEyTARQGAK |
Homo sapiens |
AGS Cell |
| pmid |
sentence |
| 33941853 |
EphA2 interacts with YES1 and phosphorylates YES1 at Tyr426 site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YES1 | up-regulates activity
phosphorylation
|
YES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247014 |
Tyr426 |
RLIEDNEyTARQGAK |
Homo sapiens |
|
| pmid |
sentence |
| 9794236 |
Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YES1 | down-regulates activity
phosphorylation
|
SOCS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276858 |
Tyr80 |
LLDACGFyWGPLSVH |
in vitro |
|
| pmid |
sentence |
| 31101761 |
SOCS1 is phosphorylated on Y80 by SRC family kinase members SRC and YES1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
YES1 | up-regulates quantity by stabilization
phosphorylation
|
SOCS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277453 |
Tyr80 |
LLDACGFyWGPLSVH |
Homo sapiens |
Lymphoma Cell Line |
| pmid |
sentence |
| 31101761 |
Samples from human lymphomas that often overexpress SOCS1 also displayed SRC family kinase activation, constitutive phosphorylation of SOCS1 on Y80, and SOCS1 cytoplasmic localization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YES1 | down-regulates activity
phosphorylation
|
YY1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276941 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26198631 |
YY1 phosphorylation is mediated by Src family kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPL10 | down-regulates
binding
|
YES1 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90805 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12138090 |
Several c-yes kinase activity assays indicated that the qm protein reduced c-yes kinase activity by 70% |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
YES1
- 
- 