Relation Results

Summary

Name COL1A2
Full Name Collagen alpha-2
Synonyms Alpha-2 type I collagen
Primary ID P08123
Links - -
Type protein
Relations 11
Pathways ECM: ECM synthesis, myCAF signaling in PDAC
Function Type I collagen is a member of group I collagen (fibrillar forming collagen).

Viewer

Type: Score: Layout: SPV 
0.4050.2470.70.3930.4220.4710.4310.4740.20.399MMP1COL1A2FLI1ECM_synthesisCOLGALT2COLGALT1A11/b1 integrinRUNX2A1/b1 integrinSMOC1TGFB1

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MMP1down-regulates quantity by destabilization img/direct_inhibition.png cleavage COL1A2 0.405
Identifier Residue Sequence Organism Cell Line
SIGNOR-272337 Gly775 NGPPGPAgSRGDGGP in vitro
pmid sentence
In vitro, MMP1 initiates degradation of native fibrillar collagens, crucial components of vertebrate extracellular matrix (ECM), by cleaving the peptide bond between Gly775–Ile776 or Gly775–Lys776 in native type I, II or III collagen molecules3,4. 
Publications: 1 Organism: In Vitro
+ FLI1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation COL1A2 0.247
Identifier Residue Sequence Organism Cell Line
SIGNOR-202685 Homo sapiens
pmid sentence
Fli1 functions as a potent transcriptional repressor of the col1a2 gene
Publications: 1 Organism: Homo Sapiens
+ COL1A2up-regulates img/direct-activation.png ECM_synthesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254663 Homo sapiens
pmid sentence
Collagen is the major structural protein in skeletal muscle ECM;...Several studies suggest that perimysial collagen is predominantly type I
Publications: 1 Organism: Homo Sapiens
+ COLGALT2up-regulates activity img/direct-activation.png glycosylation COL1A2 0.393
Identifier Residue Sequence Organism Cell Line
SIGNOR-261157 in vitro
pmid sentence
Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxylysine residues.
Publications: 1 Organism: In Vitro
+ COLGALT1up-regulates activity img/direct-activation.png glycosylation COL1A2 0.422
Identifier Residue Sequence Organism Cell Line
SIGNOR-261153 in vitro
pmid sentence
Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxylysine residues.
Publications: 1 Organism: In Vitro
+ COL1A2up-regulates activity img/direct-activation.png binding A11/b1 integrin 0.471
Identifier Residue Sequence Organism Cell Line
SIGNOR-253346 Mus musculus C2C12 Cell
pmid sentence
Modeling of the alpha I domain-collagen peptide complexes could partially explain the observed preference of different I domains for certain GFOGER sequence variations. In summary, our data indicate that the GFOGER sequence in fibrillar collagens is a common recognition motif used by alpha(1)beta(1), alpha(2)beta(1), and also alpha(11)beta(1) integrins.
Publications: 1 Organism: Mus Musculus
+ RUNX2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL1A2 0.431
Identifier Residue Sequence Organism Cell Line
SIGNOR-107166 Homo sapiens
pmid sentence
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast
Publications: 1 Organism: Homo Sapiens
+ COL1A2up-regulates activity img/direct-activation.png binding A1/b1 integrin 0.474
Identifier Residue Sequence Organism Cell Line
SIGNOR-253248 Homo sapiens K-562 Cell
pmid sentence
We have developed a cell-free assay for binding of solubilized beta1 integrins to their physiologically relevant ligands using an electrochemiluminescent detection method|Binding was clearly optimal for the presumed physiological ligands, i.e., collagen IV for a1b1, collagen I for a2b1, VCAM-Ig for a4b1, fibronectin (the 120-kDa cell attachment fragment was used) for a5b1, and laminin for a6b1.
Publications: 1 Organism: Homo Sapiens
+ SMOC1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL1A2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260404 Homo sapiens
pmid sentence
The expression of several osteoblast differentiation markers (ALP, COL1, OPN, ON, BSP and OC) was higher in SMOC1-overexpressing cells than in emptyvector-expressing cells
Publications: 1 Organism: Homo Sapiens
+ TGFB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL1A2 0.399
Identifier Residue Sequence Organism Cell Line
SIGNOR-36783 Homo sapiens
pmid sentence
Tgf-beta stimulates transcription of the human alpha 2(i) collagen gene (col1a2) promoter by increasing the affinity of an sp1-containing protein complex for its cognate dna-binding site
Publications: 1 Organism: Homo Sapiens
+ COL1A2up-regulates img/indirect-activation.png ECM_synthesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-82405 Homo sapiens
pmid sentence
The present study was designed to further characterize tgfbeta up-regulation of col1a2 and more generally, to increase our understanding of the tgfbeta signaling pathway that controls ecm accumulation.
Publications: 1 Organism: Homo Sapiens
a simple tooltip