| + |
MMP1 | down-regulates quantity by destabilization 
cleavage
|
COL1A2 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272337 |
Gly775 |
NGPPGPAgSRGDGGP |
in vitro |
|
| pmid |
sentence |
| 17318226 |
In vitro, MMP1 initiates degradation of native fibrillar collagens, crucial components of vertebrate extracellular matrix (ECM), by cleaving the peptide bond between Gly775–Ile776 or Gly775–Lys776 in native type I, II or III collagen molecules3,4. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SMOC1 | up-regulates quantity by expression 
transcriptional regulation
|
COL1A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260404 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20359165 |
The expression of several osteoblast differentiation markers (ALP, COL1, OPN, ON, BSP and OC) was higher in SMOC1-overexpressing cells than in emptyvector-expressing cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
COL1A2 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8182090 |
Tgf-beta stimulates transcription of the human alpha 2(i) collagen gene (col1a2) promoter by increasing the affinity of an sp1-containing protein complex for its cognate dna-binding site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | down-regulates quantity by repression 
transcriptional regulation
|
COL1A2 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202685 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24058639 |
Fli1 functions as a potent transcriptional repressor of the col1a2 gene |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A2 | up-regulates activity 
binding
|
A11/b1 integrin |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253346 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 12496264 |
Modeling of the alpha I domain-collagen peptide complexes could partially explain the observed preference of different I domains for certain GFOGER sequence variations. In summary, our data indicate that the GFOGER sequence in fibrillar collagens is a common recognition motif used by alpha(1)beta(1), alpha(2)beta(1), and also alpha(11)beta(1) integrins. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
COL1A2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82405 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11007770 |
The present study was designed to further characterize tgfbeta up-regulation of col1a2 and more generally, to increase our understanding of the tgfbeta signaling pathway that controls ecm accumulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COLGALT1 | up-regulates activity
glycosylation
|
COL1A2 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261153 |
|
|
in vitro |
|
| pmid |
sentence |
| 19075007 |
Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxylysine residues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
COLGALT2 | up-regulates activity
glycosylation
|
COL1A2 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261157 |
|
|
in vitro |
|
| pmid |
sentence |
| 19075007 |
Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxylysine residues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
COL1A2 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Collagen is the major structural protein in skeletal muscle ECM;...Several studies suggest that perimysial collagen is predominantly type I |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A2 | up-regulates activity
binding
|
A1/b1 integrin |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253248 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 12123670 |
We have developed a cell-free assay for binding of solubilized beta1 integrins to their physiologically relevant ligands using an electrochemiluminescent detection method|Binding was clearly optimal for the presumed physiological ligands, i.e., collagen IV for a1b1, collagen I for a2b1, VCAM-Ig for a4b1, fibronectin (the 120-kDa cell attachment fragment was used) for a5b1, and laminin for a6b1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
COL1A2
- 
- 