Summary

Name HMOX1
Full Name Heme oxygenase 1
Synonyms HO-1 | HO, HO1
Primary ID P09601
Links - -
Type protein
Relations 15
Pathways Hepatocellular Tumor
Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation HMOX1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ img/unknown.png phosphorylation HMOX1 0.583
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ down-regulates activity img/direct_inhibition.png HBA1 0.257
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HMOX1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HMOX1 0.67
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ form complex img/form-complex.png binding STC2/HMOX1 0.356
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAD 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation HMOX1 0.374
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification heme 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation HMOX1 0.67
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor