Summary

Name IMPDH2
Full Name Inosine-5'-monophosphate dehydrogenase 2
Synonyms IMP dehydrogenase 2, IMPD 2, IMPDH 2, IMPDH-II | IMPD2
Primary ID P12268
Links - -
Type protein
Relations 14
Pathways Nucleotide Biosynthesis
Inhibitors ribavirin; Sanglifehrin A; Merimepodib; mycophenolic acid
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png chemical inhibition IMPDH2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification 5'-xanthylic acid 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IMPDH2 0.301
Publications: 2 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ down-regulates activity img/direct_inhibition.png chemical inhibition IMPDH2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AKT 0.396
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IMPDH2 0.396
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MKI67 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification IMP 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition IMPDH2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition IMPDH2 0.8
Publications: 1 Organism: In Vitro