Summary

Name CCND1
Full Name G1/S-specific cyclin-D1
Synonyms B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, PRAD1 oncogene | BCL1, PRAD1
Primary ID P24385
Links - -
Type protein
Relations 54
Pathways DNMT3A in AML
Inhibitors R547; palbociclib; 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide
Function Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation CCND1 0.14
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CCND1 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCND1 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCND1 0.2
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding CDK4 0.68
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC3 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NOTCH1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression CCND1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:DNMT3A in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.37
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Skeletal Muscle
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.38
Publications: 1 Organism: Homo Sapiens
Pathways:DNMT3A in AML
+ down-regulates img/direct_inhibition.png chemical inhibition CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png Adipogenesis 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Skeletal Muscle Differentiation 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png CCND1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MSI1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.2
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CDK6/CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CyclinD/CDK4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation CCND1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CCND1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation CCND1 0.14
Publications: 1 Organism: Homo Sapiens