| + |
IMPDH2 | up-regulates activity 
binding
|
AKT |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260961 |
|
|
Homo sapiens |
Colorectal Cancer Cell Line |
| pmid |
sentence |
| 30518405 |
We further demonstrated that IMPDH2 overexpression accelerated G1/S phase cell cycle transition by inducing increased expression of cyclin D1 and Ki-67 and downregulation of p21Cip1 and p27Kip1. More importantly, G1/S phase cell cycle transition was triggered by IMPDH2 through activation of AKT activity, downregulation of mTOR and FOXO1 transcriptional activity. There is evidence that IMPDH2 interacts with the pleckstrin homology domain of PKB/AKT in the regulation of GTP biosynthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Sanglifehrin A | down-regulates activity 
chemical inhibition
|
IMPDH2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261099 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28076787 |
We show that the mammalian target of SFA is inosine-50 -monophosphate dehydrogenase 2 (IMPDH2); Biochemical characterization reveals that PPIA-SFA does not inhibit the catalytic activity of IMPDH2 but rather, it modulates cell growth via binding to the cystathionine-b-synthase (CBS) domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates activity
phosphorylation
|
IMPDH2 |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261262 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 10930578 |
Further, we have demonstrated an in vivo association of IMPDH and PKB/Akt by co‐immunoprecipitation from COS cells expressing a constitutively active form of PKB/Akt. Finally, we were able to show that this constitutively active PKB/Akt could phosphorylate IMPDH in vitro. Thus, the interplay between PKB/Akt and IMPDH reported here could suggest that PKB/Akt activation leads to IMPDH type II activation which in turn prepares the cell for entry into S phase. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
IMPDH2 | down-regulates quantity
chemical modification
|
IMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267334 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19480389 |
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
IMPDH2 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267375 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18677108 |
Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets. C-MYC depletion did not significantly affect levels of E2F1 protein reported to regulate expression of many S-phase specific genes, but resulted in the repression of several genes encoding enzymes rate-limiting for dNTP metabolism. These included thymidylate synthase (TS), inosine monophosphate dehydrogenase 2 (IMPDH2) and phosphoribosyl pyrophosphate synthetase 2 (PRPS2). C-MYC depletion also resulted in reduction in the amounts of deoxyribonucleoside triphosphates (dNTPs) and inhibition of proliferation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267377 |
|
|
Homo sapiens |
P493-6 Cell |
| pmid |
sentence |
| 18628958 |
Here, we report that the majority of genes in human purine and pyrimidine biosynthesis pathway were induced and directly bound by c-Myc in the P493-6 human Burkitt's lymphoma model cell line. The mRNA levels of IMPDH1 and IMPDH2, the rate-limiting enzyme in purine de novo synthesis, increased with MYC induction both in vitro and in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
IMPDH2 | up-regulates quantity by expression 
transcriptional regulation
|
MKI67 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30518405 |
We further demonstrated that IMPDH2 overexpression accelerated G1/S phase cell cycle transition by inducing increased expression of cyclin D1 and Ki-67 and downregulation of p21Cip1 and p27Kip1. More importantly, G1/S phase cell cycle transition was triggered by IMPDH2 through activation of AKT activity, downregulation of mTOR and FOXO1 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IMPDH2 | up-regulates quantity
chemical modification
|
5'-xanthylic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267335 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19480389 |
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
IMPDH2 | down-regulates quantity by repression 
transcriptional regulation
|
CDKN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30518405 |
We further demonstrated that IMPDH2 overexpression accelerated G1/S phase cell cycle transition by inducing increased expression of cyclin D1 and Ki-67 and downregulation of p21Cip1 and p27Kip1. More importantly, G1/S phase cell cycle transition was triggered by IMPDH2 through activation of AKT activity, downregulation of mTOR and FOXO1 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mycophenolic acid | down-regulates activity
chemical inhibition
|
IMPDH2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261077 |
|
|
in vitro |
|
| pmid |
sentence |
| 10677226 |
Mycophenolic acid (MPA) is a species-specific inhibitor of IMPDH; mammalian IMPDHsare very sensitive to MPA |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
IMPDH2 | down-regulates quantity by repression
transcriptional regulation
|
CDKN1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260960 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30518405 |
We further demonstrated that IMPDH2 overexpression accelerated G1/S phase cell cycle transition by inducing increased expression of cyclin D1 and Ki-67 and downregulation of p21Cip1 and p27Kip1. More importantly, G1/S phase cell cycle transition was triggered by IMPDH2 through activation of AKT activity, downregulation of mTOR and FOXO1 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ribavirin | down-regulates activity
chemical inhibition
|
IMPDH2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22555152 |
Ribavirin, a well-known IMPDH inhibitor, was included as a reference drug. As expected, this compound markedly inhibited IMPDH activity in a dose-dependent manner in bothtumour cell lines |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IMPDH2 | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30518405 |
We further demonstrated that IMPDH2 overexpression accelerated G1/S phase cell cycle transition by inducing increased expression of cyclin D1 and Ki-67 and downregulation of p21Cip1 and p27Kip1. More importantly, G1/S phase cell cycle transition was triggered by IMPDH2 through activation of AKT activity, downregulation of mTOR and FOXO1 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Merimepodib | down-regulates activity
chemical inhibition
|
IMPDH2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261106 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11288107 |
These studies demonstrate that VX-497 is a potent, specific, and reversible IMPDH inhibitor that selectively inhibits lymphocyte proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IMPDH2
- 
- 