Name F3
Full Name Tissue factor
Synonyms TF, Coagulation factor III, Thromboplastin
Primary ID P13726
Links - -
Type protein
Relations 3
Function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.


Modifications Tables


Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation F3 0.04
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation F3 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation F3
Publications: 1 Organism: Homo Sapiens