3.0
Summary
| Name |  F3View Modifications |
| Full Name | Tissue factor |
| Synonyms | TF, Coagulation factor III, Thromboplastin |
| Primary ID | P13726 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | up-regulates 
phosphorylation
|
F3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK14 | down-regulates 
phosphorylation
|
F3 | 0.296 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Blood vessel damage | up-regulates 
|
F3 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Blood Plasma | |||
| + | NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
F3 | 0.252 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | F3 | form complex 
binding
|
Factor FVIIa:TF | 0.932 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Blood Plasma | |||