| + |
MIF | down-regulates quantity by destabilization 
relocalization
|
SOD1 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262797 |
|
|
Mus musculus |
NSC-34 Cell |
| pmid |
sentence |
| 29371591 |
Here, we show that MIF inhibits mutant SOD1 nuclear clearance when overexpressed in motor neuron-like NSC-34 cells|SOD1WT is evenly distributed between the cytoplasm and the nucleus while mutant SOD1G93A shows predominantly cytoplasmic distribution (Fig. 1a, b). Expression of MIF in cells expressing SOD1WT had no effect on the distribution of the SOD1WT–EGFP protein. However, expression of MIF together with the mutant SOD1G93A–EGFP, inhibited the nuclear clearance of misfolded SOD1 resulting in a more wild-type-like distribution of the mutant SOD1 protein |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MIF | up-regulates activity 
binding
|
CD74 |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12782713 |
MIF binds to the extracellular domain of CD74, and CD74 is required for MIF-induced activation of the extracellular signal-regulated kinase-1/2 MAP kinase cascade, cell proliferation, and PGE2 production |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Toll like receptors |
| + |
MIF | up-regulates activity
binding
|
CXCR4 |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252062 |
|
|
Mus musculus |
Monocyte |
| pmid |
sentence |
| 17435771 |
We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF [] By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Toll like receptors |
| + |
MIF | down-regulates quantity by repression 
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251832 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 16636133 |
MIF inhibits cytodifferentiation and hemoglobin synthesis of MEL cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIF | up-regulates activity
binding
|
CXCR2 |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252061 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17435771 |
We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF [] By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Toll like receptors |
| + |
MIF | down-regulates quantity by repression
transcriptional regulation
|
HBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251831 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16636133 |
MIF inhibits cytodifferentiation and hemoglobin synthesis of MEL cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIF | up-regulates
binding
|
CD74 |
0.725 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101526 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12782713 |
Mif binds to the extracellular domain of cd74, and cd74 is required for mif-induced activation of the extracellular signal-regulated kinase-1/2 map kinase cascade, cell proliferation, and pge2 production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Toll like receptors |
3.0
MIF
- 
- 