Summary

Name IRF2
Full Name Interferon regulatory factor 2
Synonyms IRF-2
Primary ID P14316
Links - -
Type protein
Relations 5
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding IRF2 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IRF2 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IRF2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DST 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TAP1 0.08
Publications: 1 Organism: Homo Sapiens