| + |
CSF3 | up-regulates 
binding
|
CSF2RA |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10572088 |
Granulocyte-macrophage colony-stimulating factor (gm-csf) is an important hematopoietic cytokine that exerts its effects by interaction with the gm-csf receptor (gmr) on the surface of responsive cells. The gm-csf receptor consists of two subunits: gmralpha, which binds gm-csf with low affinity, and gmrbeta, which lacks intrinsic ligand-binding capability but complexes with gmralpha to form a high-affinity receptor (gmralpha/beta). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSF2 | up-regulates activity
binding
|
CSF2RA |
0.851 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249501 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 18551128 |
The GM-CSF receptor (CSF2R) is a heterodimer composed of a specific ligand-binding subunit (CSF2Ralpha) and a common signal-transduction subunit (CSF2Rbeta) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSF1 | up-regulates
binding
|
CSF2RA |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10572088 |
Granulocyte-macrophage colony-stimulating factor (gm-csf) is an important hematopoietic cytokine that exerts its effects by interaction with the gm-csf receptor (gmr) on the surface of responsive cells. The gm-csf receptor consists of two subunits: gmralpha, which binds gm-csf with low affinity, and gmrbeta, which lacks intrinsic ligand-binding capability but complexes with gmralpha to form a high-affinity receptor (gmralpha/beta). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK2 | up-regulates activity
phosphorylation
|
CSF2RA |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249503 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 8977526 |
JAK2 is a primary kinase regulating all the known activities of GM-CSF. JAK2 mediates GM-CSF induced c-fos activation through receptor phosphorylation and Shc/PTP 1D activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSF2RA | form complex 
binding
|
CSF2RA/CSF2RB |
0.864 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9680354 |
The high-affinity GMR is known to be composed of a specific ligand-binding alpha subunit (GMRα) and a common beta subunit (βc), which is also a component of the interleukins-3 (IL-3) and -5 (IL-5) receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSF2RA | up-regulates activity
binding
|
JAK2 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249502 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8977526 |
JAK2 is a primary kinase regulating all the known activities of GM-CSF. JAK2 mediates GM-CSF induced c-fos activation through receptor phosphorylation and Shc/PTP 1D activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSF2RA | up-regulates 
|
JAK2 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46334 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9028317 |
We show that the amount of jak2 physically associated with gm-csfr beta chain is increased after gm-csf stimulation and that gm-csf triggers both beta chain and jak2 tyrosine phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSF2 | up-regulates
binding
|
CSF2RA |
0.851 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49126 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9187659 |
We have determined the nmr structure of a ligand-binding domain of the granulocyte colony-stimulating factor (g-csf) receptor comparisons between the spectra of the 15n-labelled domain with and without g-csf indicate that the major ligand-recognition site is on the fg loop just upstream of the wsxws sequence. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72458 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10572088 |
We have determined the nmr structure of a ligand-binding domain of the granulocyte colony-stimulating factor (g-csf) receptor comparisons between the spectra of the 15n-labelled domain with and without g-csf indicate that the major ligand-recognition site is on the fg loop just upstream of the wsxws sequence. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSF2RA | up-regulates
|
STAT5A |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-32220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7716810 |
A major pathway which mediates the effects of gm-csf on macrophages involves activation of the latent transcription factor stat5a via a janus kinase 2 (jak2)-dependent pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CSF2RA
- 
- 