| + |
SMO | up-regulates 
binding
|
GNB3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling as pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148592 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling as pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199180 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling as pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
GNB3 | up-regulates
binding
|
PI3K |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14668344 |
Expression of the g__ sequestrant, _-transducin, inhibits both ras activation and membrane translocation of _-arrestin1, suggesting that g__ dimers from g_i2 and g_q activate different effectors to coordinately regulate the pi 3-kinase/akt pathway. , these data indicate that _-thrombin stimulates rapid pi 3-kinase activity and akt phosphorylation by the g__ dimers released from a ptx-sensitive g protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD3 | up-regulates
binding
|
GNB3 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152603 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
In the non-canonical wnt pathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB3 | up-regulates
binding
|
PLCG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199135 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Furthermore, this work suggested that the g subunits released upon gi activation activated phospholipase c (plc- ) to produce inositol 3-phosphate (ip3), which would subsequently increase intracellular ca2+ abundance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
lysophosphatidic acids | up-regulates
chemical activation
|
GNB3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Lpa through galfai and gbetagamma subunits also activates phosphatidylinositol 3-kinase (pi3k), which results in the stimulation of the akt survival pathway and increased protein translation by the activation of the mammalian target of rapamycin (mtor) pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB3 | up-regulates
binding
|
PIK3CA |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-120264 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14668344 |
Expression of the g__ sequestrant, _-transducin, inhibits both ras activation and membrane translocation of _-arrestin1, suggesting that g__ dimers from g_i2 and g_q activate different effectors to coordinately regulate the pi 3-kinase/akt pathway. , these data indicate that _-thrombin stimulates rapid pi 3-kinase activity and akt phosphorylation by the g__ dimers released from a ptx-sensitive g protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTGER3 | up-regulates
binding
|
GNB3 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88192 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12038972 |
Ep3 receptor signals are primarily involved in adenylyl cyclase via g(i) activation, and in ca(2+)-mobilization through g(beta)(gamma) from g(i) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GNB3
- 
- 