| + |
TNFRSF1B | up-regulates activity 
|
MAPK14 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253603 |
|
|
|
|
| pmid |
sentence |
| 20887952 |
These results indicate that TNF-a-activated p38 pathway negatively controls the expansion of PAX7-positive SCs |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253601 |
|
|
|
|
| pmid |
sentence |
| 17151142 |
[...] TNF-alpha is critical for p38 activation during the early stages of myoblast differentiation |
|
| Publications: |
2 |
| + |
ASB3 | down-regulates quantity by destabilization 
binding
|
TNFRSF1B |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271546 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15899873 |
While the ankyrin repeats of ASB3 interact with the C-terminal 37 amino acids of TNF-R2, the SOCS box of ASB3 is responsible for recruiting the E3 ubiquitin ligase adaptors Elongins-B/C, leading to TNF-R2 ubiquitination on multiple lysine residues within its C-terminal region. Downregulation of ASB3 expression by a small interfering RNA inhibited TNF-R2 degradation and potentiated TNF-R2-mediated cytotoxicity. The data presented here implicate ASB3 as a negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of TNF-R2 for ubiquitination and proteasome-mediated degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFRSF1B | up-regulates
|
TRAF1 |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8069916 |
Traf1 interacts with tnf-r2 indirectly through heterodimer formation with traf2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
| + |
TNF | up-regulates activity 
binding
|
TNFRSF1B |
0.928 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253592 |
|
|
|
|
| pmid |
sentence |
| 17151142 |
These data indicate that myogenic activation of p38 requires TNF-alpha receptor-mediated signaling |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253594 |
|
|
|
|
| pmid |
sentence |
| 14732063 |
[...] two distinct types of TNF-Rs have been identified and molecularly cloned: TNF-R55 (also referred to as TNFR1, p55 or CD120a) and TNF-R75 (also called TNFR2, p75 or CD120b) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88216 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12040173 |
The binding of tnf to tnf-r1 triggers a series of intracellular events that ultimately result in the activation of two major transcription factors, nuclear factor kb (nf-kb) and c-jun. |
|
| Publications: |
3 |
Organism: |
, Homo Sapiens |
| + |
TNFRSF1B | up-regulates activity
binding
|
TRAF2 |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34645 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8069916 |
Our analysis indicates that traf1 and traf2 are associated with the cytoplasmic domain of tnf-r2 in a heterodimeric complex in which traf2 contacts the receptor directly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
| + |
VCB-Cul2 | down-regulates quantity by destabilization
polyubiquitination
|
TNFRSF1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271545 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15899873 |
While the ankyrin repeats of ASB3 interact with the C-terminal 37 amino acids of TNF-R2, the SOCS box of ASB3 is responsible for recruiting the E3 ubiquitin ligase adaptors Elongins-B/C, leading to TNF-R2 ubiquitination on multiple lysine residues within its C-terminal region. Downregulation of ASB3 expression by a small interfering RNA inhibited TNF-R2 degradation and potentiated TNF-R2-mediated cytotoxicity. The data presented here implicate ASB3 as a negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of TNF-R2 for ubiquitination and proteasome-mediated degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFRSF1B | up-regulates
binding
|
TRAF1 |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33133 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8069916 |
Traf1 interacts with tnf-r2 indirectly through heterodimer formation with traf2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
3.0
TNFRSF1B
- 
- 