Relation Results

Summary

Name TNFRSF1B
Full Name Tumor necrosis factor receptor superfamily member 1B
Synonyms Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor | TNFBR, TNFR2
Primary ID P20333
Links - -
Type protein
Relations 11
Pathways SAPK/JNK Signaling
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 co ...
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Type: Score: Layout: SPV 
0.930.40.20.3020.7180.3270.706TNFTNFRSF1BASB3VCB-Cul2MAPK14TRAF1SMURF2TRAF2

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Relations
Regulator
Mechanism
target
score ℹ
+ TNFup-regulates activity img/direct-activation.png binding TNFRSF1B 0.93
Identifier Residue Sequence Organism Cell Line
SIGNOR-253594
pmid sentence
[...] two distinct types of TNF-Rs have been identified and molecularly cloned: TNF-R55 (also referred to as TNFR1, p55 or CD120a) and TNF-R75 (also called TNFR2, p75 or CD120b)
Identifier Residue Sequence Organism Cell Line
SIGNOR-88216 Homo sapiens
pmid sentence
The binding of tnf to tnf-r1 triggers a series of intracellular events that ultimately result in the activation of two major transcription factors, nuclear factor kb (nf-kb) and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-253592
pmid sentence
These data indicate that myogenic activation of p38 requires TNF-alpha receptor-mediated signaling
Publications: 3 Organism: , Homo Sapiens
+ ASB3down-regulates quantity by destabilization img/direct_inhibition.png binding TNFRSF1B 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-271546 Homo sapiens HEK-293 Cell
pmid sentence
While the ankyrin repeats of ASB3 interact with the C-terminal 37 amino acids of TNF-R2, the SOCS box of ASB3 is responsible for recruiting the E3 ubiquitin ligase adaptors Elongins-B/C, leading to TNF-R2 ubiquitination on multiple lysine residues within its C-terminal region. Downregulation of ASB3 expression by a small interfering RNA inhibited TNF-R2 degradation and potentiated TNF-R2-mediated cytotoxicity. The data presented here implicate ASB3 as a negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of TNF-R2 for ubiquitination and proteasome-mediated degradation
Publications: 1 Organism: Homo Sapiens
+ VCB-Cul2down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TNFRSF1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271545 Homo sapiens HEK-293 Cell
pmid sentence
While the ankyrin repeats of ASB3 interact with the C-terminal 37 amino acids of TNF-R2, the SOCS box of ASB3 is responsible for recruiting the E3 ubiquitin ligase adaptors Elongins-B/C, leading to TNF-R2 ubiquitination on multiple lysine residues within its C-terminal region. Downregulation of ASB3 expression by a small interfering RNA inhibited TNF-R2 degradation and potentiated TNF-R2-mediated cytotoxicity. The data presented here implicate ASB3 as a negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of TNF-R2 for ubiquitination and proteasome-mediated degradation
Publications: 1 Organism: Homo Sapiens
+ TNFRSF1Bup-regulates activity img/indirect-activation.png MAPK14 0.302
Identifier Residue Sequence Organism Cell Line
SIGNOR-253603
pmid sentence
These results indicate that TNF-a-activated p38 pathway negatively controls the expansion of PAX7-positive SCs
Identifier Residue Sequence Organism Cell Line
SIGNOR-253601
pmid sentence
[...] TNF-alpha is critical for p38 activation during the early stages of myoblast differentiation
Publications: 2
+ TNFRSF1Bup-regulates img/direct-activation.png binding TRAF1 0.718
Identifier Residue Sequence Organism Cell Line
SIGNOR-33133 Homo sapiens
pmid sentence
Traf1 interacts with tnf-r2 indirectly through heterodimer formation with traf2.
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ TNFRSF1Bup-regulates img/indirect-activation.png TRAF1 0.718
Identifier Residue Sequence Organism Cell Line
SIGNOR-33843 Homo sapiens
pmid sentence
Traf1 interacts with tnf-r2 indirectly through heterodimer formation with traf2.
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ SMURF2up-regulates activity img/direct-activation.png ubiquitination TNFRSF1B 0.327
Identifier Residue Sequence Organism Cell Line
SIGNOR-278716 Homo sapiens
pmid sentence
However, co-transfection of Smurf2, but not Smurf2-C/A, drastically increased the potential of TNF-R2 to induce JNK phosphorylation.|In conclusion, these results indicate that Smurf2 is able to ubiquitinate TNF-R2, which is further enhanced by the TRAF2-mediated targeting of Smurf2 to TNF-R2.
Publications: 1 Organism: Homo Sapiens
+ TNFRSF1Bup-regulates activity img/direct-activation.png binding TRAF2 0.706
Identifier Residue Sequence Organism Cell Line
SIGNOR-34645 Homo sapiens
pmid sentence
Our analysis indicates that traf1 and traf2 are associated with the cytoplasmic domain of tnf-r2 in a heterodimeric complex in which traf2 contacts the receptor directly.
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
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