Summary

Name TRAF1
Full Name TNF receptor-associated factor 1
Synonyms Epstein-Barr virus-induced protein 6 | EBI6
Primary ID Q13077
Links - -
Type protein
Relations 8
Pathways SAPK/JNK Signaling
Function Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

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Relations

Regulator Mechanism target score ℹ
+ LUBACup-regulates activity img/direct-activation.png polyubiquitination TRAF1 0.365
Publications: 1 Organism: Homo Sapiens
+ TRAF2up-regulates img/direct-activation.png binding TRAF1 0.618
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ NFKB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRAF1 0.543
Publications: 1 Organism: Homo Sapiens
+ TNFRSF1Bup-regulates img/direct-activation.png binding TRAF1 0.709
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ TRAF1up-regulates img/direct-activation.png binding TRAF2 0.618
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ RELAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRAF1 0.531
Publications: 1 Organism: Homo Sapiens
+ TNFRSF1Bup-regulates img/indirect-activation.png TRAF1 0.709
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ TRADDup-regulates img/direct-activation.png binding TRAF1 0.682
Publications: 1 Organism: Homo Sapiens