| + |
CDK11B | up-regulates activity 
phosphorylation
|
EIF3F |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273133 |
Ser46 |
PAAAPASsSDPAAAA |
|
|
| pmid |
sentence |
| 19245811 |
EIF3f is phosphorylated by CDK11p46 at Ser46 during apoptosis.|Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273131 |
Thr119 |
GAARVIGtLLGTVDK |
|
|
| pmid |
sentence |
| 19245811 |
Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis. |
|
| Publications: |
2 |
| + |
CDK11B | down-regulates 
phosphorylation
|
EIF3F |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95762 |
Ser46 |
PAAAPASsSDPAAAA |
Homo sapiens |
|
| pmid |
sentence |
| 12446680 |
The interaction between cdk11p46 and eif3 p47 occurs in vitro and in vivo. In addition, cdk11 protein kinase isolated from cells undergoing apoptosis can phosphorylate eif3 p47in vitro, and serine phosphorylation of eif3 p47 occurs in cells during apoptosis.Purified recombinant cdk11p46 inhibited translation of a reporter gene in vitro in a dose-dependent manner.These data suggest that the function of the caspase-processed cdk11p110 isoform may be to inhibit translation during apoptosis. However, whether or not this inhibition of protein translation occurs in an eif3 p47-dependent or -independent manner remains to be clarified. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK11B |
phosphorylation
|
EIF3F |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184185 |
Thr119 |
GAARVIGtLLGTVDK |
Homo sapiens |
|
| pmid |
sentence |
| 19245811 |
Here, we identified a second eif3f phosphorylation site (thr119) by cdk11p46 during apoptosis.Thr119 is located in the mov34 domain of eif3f which is important for both the translational inhibitory function of eif3ffurther studies of how eif3f phosphorylation regulates its function will refine insights into the mechanism and regulation of translation initiation, apoptotic signaling, and tumorigenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK7 | up-regulates activity
phosphorylation
|
CDK11B |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245871 |
Thr595 |
GSPLKAYtPVVVTLW |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16327805 |
We conclude that CDK7 phsphorylates Cdk11, dependent on the conserved Thr219 residue in the CDK11 T loop, and it is therefore likely to be a genuine Cdk11 activating kinase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK11A | up-regulates
phosphorylation
|
CDK11B |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169628 |
Thr726 |
KHEYFREtPLPIDPS |
Homo sapiens |
|
| pmid |
sentence |
| 21078675 |
Overall, our data indicated that thr-370 is responsible for the autophosphorylation, dimerization, and kinase activity of cdk11(p58) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK11B | form complex 
binding
|
CyclinD3/CDK11B |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273119 |
|
|
in vitro |
|
| pmid |
sentence |
| 12082095 |
We found that AR was phosphorylated at Ser-308 by cyclin D3/CDK11p58 in vitro and in vivo, leading to the repressed activity of AR transcriptional activation unit 1 (TAU1). |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
CDK11B
- 
- 