3.0
Summary
| Name |  RPS3View Modifications |
| Full Name | 40S ribosomal protein S3 |
| Synonyms | RS3_HUMAN |
| Primary ID | P23396 |
| Links |  -  -  |
| Type | protein |
| Relations | 17 |
| Function | Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCD | up-regulates 
phosphorylation
|
RPS3 | 0.2 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | PPP2CA | down-regulates 
dephosphorylation
|
RPS3 | 0.402 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCD | up-regulates activity
phosphorylation
|
RPS3 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates
phosphorylation
|
RPS3 | 0.371 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 |
phosphorylation
|
RPS3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | up-regulates
phosphorylation
|
RPS3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 | up-regulates
phosphorylation
|
RPS3 | 0.359 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 |
phosphorylation
|
RPS3 | 0.359 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | up-regulates activity
phosphorylation
|
RPS3 | 0.377 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | AKT | up-regulates activity
phosphorylation
|
RPS3 | 0.2 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | ERK1/2 |
phosphorylation
|
RPS3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS3 | form complex 
binding
|
40S cytosolic small ribosomal subunit | 0.889 |
| Publications: | 1 | Organism: | In Vitro | |
| + | Gbeta |
phosphorylation
|
RPS3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Host translation inhibitor nsp1 | down-regulates activity
binding
|
RPS3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |