4.0
Satellite: IL1
Pathway ID: SIGNOR-ScIL1SEC
Description: IL1 secreted from inflammatory cells, such as macrophages, plays a role in promoting satellite cell proliferation, while inhibiting their myogenic commitment. The IL1 pathway acts mainly through NF-kB, which can induce the transcription of several inflammatory cytokines, including IL1, which can in turn promote further NF-kB activation via a positive feedback loop.
Curated by: Alessandro Palma
Description: IL1 secreted from inflammatory cells, such as macrophages, plays a role in promoting satellite cell proliferation, while inhibiting their myogenic commitment. The IL1 pathway acts mainly through NF-kB, which can induce the transcription of several inflammatory cytokines, including IL1, which can in turn promote further NF-kB activation via a positive feedback loop.
Curated by: Alessandro Palma
19 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| NfKb-p65/p50 | SIGNOR-C13 |
| MYD88 | Q99836 |
| Proliferation | SIGNOR-PH4 |
| IRAK1 | P51617 |
| NOS2 | P35228 |
| TRAF6 | Q9Y4K3 |
| Skeletal_muscle_differentiation | SIGNOR-PH1 |
| IL1R1 | P14778 |
| CCND1 | P24385 |
| IL6 | P05231 |
| CCL2 | P13500 |
| MYOD1 | P15172 |
| MAP3K7 | O43318 |
| NFKBIA | P25963 |
| TAB2 | Q9NYJ8 |
| TNF | P01375 |
| IKK-complex | SIGNOR-C14 |
| IL1B | P01584 |
| IL1A | P01583 |