3.0
Summary
| Name |  PTBP1View Modifications |
| Full Name | Polypyrimidine tract-binding protein 1 |
| Synonyms | PTB, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I | PTB |
| Primary ID | P26599 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | down-regulates activity 
phosphorylation
|
PTBP1 | 0.313 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | PTBP1 | up-regulates 
|
Alternative_Splicing_Regulation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAVER1 | up-regulates activity 
binding
|
PTBP1 | 0.508 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MYC | up-regulates quantity by expression
transcriptional regulation
|
PTBP1 | 0.451 |
| Publications: | 1 | Organism: | Homo Sapiens | |