Relation Results

Summary

Name POU1F1
Full Name Pituitary-specific positive transcription factor 1
Synonyms PIT-1, Growth hormone factor 1, GHF-1 | GHF1, PIT1
Primary ID P28069
Links - -
Type protein
Relations 6
Pathways Thyroid Hormone Metabolism
Function Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Spe ...
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Type: Score: Layout: SPV 
0.4730.5170.3820.360.441PITX1POU1F1LHX4CREBBPGH1TSHB

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Relations
Regulator
Mechanism
target
score ℹ
+ PITX1up-regulates activity img/direct-activation.png binding POU1F1 0.473
Identifier Residue Sequence Organism Cell Line
SIGNOR-219740 in vitro
pmid sentence
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters.
Publications: 1 Organism: In Vitro
+ LHX4up-regulates quantity by expression img/indirect-activation.png transcriptional regulation POU1F1 0.517
Identifier Residue Sequence Organism Cell Line
SIGNOR-254558 Homo sapiens
pmid sentence
We show that normal LHX4 binds to a human-specific element and subsequently activates transcription from the proximal upstream regulatory sequence of POUIF1, a gene encoding a POU homeodomain transcription factor known as the main regulator of GH expression.
Publications: 1 Organism: Homo Sapiens
+ CREBBPup-regulates activity img/direct-activation.png binding POU1F1 0.382
Identifier Residue Sequence Organism Cell Line
SIGNOR-267204 Homo sapiens
pmid sentence
 We and others have recently shown that CBP can constitutively bind to Pit-1 and synergistically activate transcription of promoters containing Pit-1 DNA-binding sites.
Publications: 1 Organism: Homo Sapiens
Tissue: Thyroid Gland
Pathways:Thyroid Hormone Metabolism
+ POU1F1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GH1 0.36
Identifier Residue Sequence Organism Cell Line
SIGNOR-254559 Homo sapiens
pmid sentence
Such findings are consistent with the existence, in humans, of an LHX4-driven pathway leading to the expression of GH through transcriptional activation of POU1F1.
Publications: 1 Organism: Homo Sapiens
+ POU1F1up-regulates quantity by expression img/direct-activation.png transcriptional regulation TSHB 0.441
Identifier Residue Sequence Organism Cell Line
SIGNOR-267205 Homo sapiens
pmid sentence
CBP and Pit-1 acted synergistically in TRH stimulation of the TSH-β promoter. The human TSH-β promoter contains three well defined Pit-1 DNA-binding sites.
Publications: 1 Organism: Homo Sapiens
Tissue: Thyroid Gland
Pathways:Thyroid Hormone Metabolism
+ LHX4up-regulates quantity by expression img/direct-activation.png transcriptional regulation POU1F1 0.517
Identifier Residue Sequence Organism Cell Line
SIGNOR-266056 Cricetulus griseus CHO Cell
pmid sentence
We show that normal LHX4 binds to a human-specific element and subsequently activates transcription from the proximal upstream regulatory sequence of POUIF1, a gene encoding a POU homeodomain transcription factor known as the main regulator of GH expression.
Publications: 1 Organism: Cricetulus Griseus
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