| + |
LHX4 | up-regulates quantity by expression 
transcriptional regulation
|
POU1F1 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254558 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15998782 |
We show that normal LHX4 binds to a human-specific element and subsequently activates transcription from the proximal upstream regulatory sequence of POUIF1, a gene encoding a POU homeodomain transcription factor known as the main regulator of GH expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU1F1 | up-regulates quantity by expression
transcriptional regulation
|
GH1 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254559 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15998782 |
Such findings are consistent with the existence, in humans, of an LHX4-driven pathway leading to the expression of GH through transcriptional activation of POU1F1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PITX1 | up-regulates activity 
binding
|
POU1F1 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219740 |
|
|
in vitro |
|
| pmid |
sentence |
| 8755540 |
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CREBBP | up-regulates activity
binding
|
POU1F1 |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10931853 |
We and others have recently shown that CBP can constitutively bind to Pit-1 and synergistically activate transcription of promoters containing Pit-1 DNA-binding sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| Pathways: | Thyroid Hormone Metabolism |
| + |
POU1F1 | up-regulates quantity by expression
transcriptional regulation
|
TSHB |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10931853 |
CBP and Pit-1 acted synergistically in TRH stimulation of the TSH-β promoter. The human TSH-β promoter contains three well defined Pit-1 DNA-binding sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| Pathways: | Thyroid Hormone Metabolism |
| + |
LHX4 | up-regulates quantity by expression
transcriptional regulation
|
POU1F1 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266056 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 15998782 |
We show that normal LHX4 binds to a human-specific element and subsequently activates transcription from the proximal upstream regulatory sequence of POUIF1, a gene encoding a POU homeodomain transcription factor known as the main regulator of GH expression. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
3.0
POU1F1
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