| + |
GH1 | up-regulates quantity by expression 
transcriptional regulation
|
CCND1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261629 |
|
|
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 15665309 |
Autocrine hGH increased the transcription and subsequent mRNA level and protein expression of c-Myc, Cyclin D1, and Bcl-2 in human mammary epithelial cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU1F1 | up-regulates quantity by expression 
transcriptional regulation
|
GH1 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254559 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15998782 |
Such findings are consistent with the existence, in humans, of an LHX4-driven pathway leading to the expression of GH through transcriptional activation of POU1F1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GH1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261627 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15665309 |
Autocrine hGH increased the transcription and subsequent mRNA level and protein expression of c-Myc, Cyclin D1, and Bcl-2 in human mammary epithelial cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GH1 | up-regulates
binding
|
GHR |
0.854 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7862673 |
The hghr only binds primate gh. Arg43 in hghr interacts with asp171 of hgh. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GH1 | up-regulates quantity by expression
transcriptional regulation
|
BCL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261628 |
|
|
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 15665309 |
Autocrine hGH increased the transcription and subsequent mRNA level and protein expression of c-Myc, Cyclin D1, and Bcl-2 in human mammary epithelial cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GH1 | up-regulates activity
binding
|
GHR |
0.854 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7862673 |
Although growth hormone (GH) receptors (GHRs) in many species bind human (h) GH as well as their own GH, the hGHR only binds primate GH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GH1 | up-regulates
binding
|
PRLR |
0.766 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-35575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7984244 |
Hprl does not bind to the hgh receptor, but hgh binds to both the hghr and hprlr, and mutagenesis studies have shown that the receptor-binding sites on hgh overlap. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNF292 | up-regulates quantity by expression
transcriptional regulation
|
GH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268969 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10687855 |
Rat Zn-15 is a transcription factor activating GH gene expression by synergistic interactions with Pit-1, named for 15 DNA-binding zinc fingers, including fingers IX, X, and XI that are responsible for GH promoter binding. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
GH1
- 
- 