| + |
CD38 | down-regulates quantity 
chemical modification
|
NADP(+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264247 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18626062 |
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ribose (cADPR), NAADP, and ADPR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PECAM1 | up-regulates activity 
binding
|
CD38 |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18626062 |
As a receptor, CD38 interacts with its ligand CD31 [15,16]. CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a 130 kDa type I transmembrane glycoprotein that consists of six extracellular immunoglobulin-like homology domains, a 19-residue transmembrane domain, and a 118-residue cytoplasmic tail |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD38 | up-regulates quantity 
relocalization
|
OXT |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268544 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17287729 |
CD38 is critical for social behaviour by regulating oxytocin secretion|Consistently, the plasma level of oxytocin (OT), but not vasopressin, was strongly decreased in CD38-/- mice. Replacement of OT by subcutaneous injection or lentiviral-vector-mediated delivery of human CD38 in the hypothalamus rescued social memory and maternal care in CD38-/- mice. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Oxytocin signaling |
| + |
CD38 | up-regulates quantity
chemical modification
|
cyclic ADP-ribose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264244 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18626062 |
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ribose (cADPR), NAADP, and ADPR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD38 | up-regulates quantity
chemical modification
|
nicotinic acid-adenine dinucleotide phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264245 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18626062 |
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ribose (cADPR), NAADP, and ADPR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD38 | down-regulates quantity
chemical modification
|
NMN(+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18626062 |
CD38 is also able to catalyze the degradation of the NAD precursor nicotinamide mono-nucleotide (NMN) into nicotinamide |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD38 | up-regulates quantity
chemical modification
|
nicotinamide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18626062 |
CD38 is also able to catalyze the degradation of the NAD precursor nicotinamide mono-nucleotide (NMN) into nicotinamide |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD38 | down-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264255 |
|
|
Homo sapiens |
Microglia |
| pmid |
sentence |
| 18626062 |
CD38 knockdown was found to increase apoptosis in normal microglia, but played a protective role in LPS-stimulated microglia and reduced proinflammatory cytokine secretion (Figure 1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD38 | down-regulates quantity
chemical modification
|
NAD(+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264246 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18626062 |
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ribose (cADPR), NAADP, and ADPR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CD38
- 
- 