Relation Results

Summary

Name PECAM1
Full Name Platelet endothelial cell adhesion molecule
Synonyms PECAM-1, EndoCAM, GPIIA', PECA1 |
Primary ID P16284
Links - -
Type protein
Relations 8
Function Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17 ...
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Type: Score: Layout: SPV 
0.2770.3250.5450.5830.4880.2FESPECAM1FERCSKLCKCD38NUP98-HOXA9

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ FESup-regulates activity img/direct-activation.png phosphorylation PECAM1 0.277
Identifier Residue Sequence Organism Cell Line
SIGNOR-262867 Tyr690 PLNSDVQyTEVQVSS Homo sapiens HEK-293 Cell
pmid sentence
PECAM-1 Is Phosphorylated by Fer and, To a Lesser Extent, by Fes. These results suggest that Fer not only functions as a tyrosine kinase for PECAM-1 but also that Fer modulates the downstream signaling of PECAM-1 by inducing phosphorylation of SHP-2 and Gab1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262868 Tyr713 KKDTETVySEVRKAV Homo sapiens HEK-293 Cell
pmid sentence
PECAM-1 Is Phosphorylated by Fer and, To a Lesser Extent, by Fes. These results suggest that Fer not only functions as a tyrosine kinase for PECAM-1 but also that Fer modulates the downstream signaling of PECAM-1 by inducing phosphorylation of SHP-2 and Gab1.
Publications: 2 Organism: Homo Sapiens
+ FERup-regulates activity img/direct-activation.png phosphorylation PECAM1 0.325
Identifier Residue Sequence Organism Cell Line
SIGNOR-262865 Tyr690 PLNSDVQyTEVQVSS Homo sapiens HEK-293 Cell
pmid sentence
PECAM-1 Is Phosphorylated by Fer and, To a Lesser Extent, by Fes. These results suggest that Fer not only functions as a tyrosine kinase for PECAM-1 but also that Fer modulates the downstream signaling of PECAM-1 by inducing phosphorylation of SHP-2 and Gab1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262866 Tyr713 KKDTETVySEVRKAV Homo sapiens HEK-293 Cell
pmid sentence
PECAM-1 Is Phosphorylated by Fer and, To a Lesser Extent, by Fes. These results suggest that Fer not only functions as a tyrosine kinase for PECAM-1 but also that Fer modulates the downstream signaling of PECAM-1 by inducing phosphorylation of SHP-2 and Gab1.
Publications: 2 Organism: Homo Sapiens
+ CSKup-regulates activity img/direct-activation.png phosphorylation PECAM1 0.545
Identifier Residue Sequence Organism Cell Line
SIGNOR-262741 Tyr713 KKDTETVySEVRKAV Chlorocebus aethiops COS-1 Cell
pmid sentence
We demonstrated that phosphorylation of PECAM-1 by Src or Csk family kinases was sufficient to trigger its association with SHP-2. Moreover, it was able to promote binding of PECAM-1 to SHP-1, a SHP-2-related protein-tyrosine phosphatase expressed in hemopoietic cells. Taken together, these findings indicated that the Src and Csk families of kinases are strong candidates for mediating tyrosine phosphorylation of PECAM-1 and triggering its association with SH2 domain-containing phosphatases under physiological circumstances.
Publications: 1 Organism: Chlorocebus Aethiops
+ LCKup-regulates activity img/direct-activation.png phosphorylation PECAM1 0.583
Identifier Residue Sequence Organism Cell Line
SIGNOR-262742 Tyr713 KKDTETVySEVRKAV Chlorocebus aethiops
pmid sentence
We demonstrated that phosphorylation of PECAM-1 by Src or Csk family kinases was sufficient to trigger its association with SHP-2. Moreover, it was able to promote binding of PECAM-1 to SHP-1, a SHP-2-related protein-tyrosine phosphatase expressed in hemopoietic cells. Taken together, these findings indicated that the Src and Csk families of kinases are strong candidates for mediating tyrosine phosphorylation of PECAM-1 and triggering its association with SH2 domain-containing phosphatases under physiological circumstances.
Publications: 1 Organism: Chlorocebus Aethiops
+ PECAM1up-regulates activity img/direct-activation.png binding CD38 0.488
Identifier Residue Sequence Organism Cell Line
SIGNOR-264254 Homo sapiens
pmid sentence
As a receptor, CD38 interacts with its ligand CD31 [15,16]. CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a 130 kDa type I transmembrane glycoprotein that consists of six extracellular immunoglobulin-like homology domains, a 19-residue transmembrane domain, and a 118-residue cytoplasmic tail
Publications: 1 Organism: Homo Sapiens
+ NUP98-HOXA9down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PECAM1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261500 Homo sapiens
pmid sentence
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. The platelet endothelial cell adhesion molecule PECAM1 is also downregulated by NUP98‐HOXA9.
Publications: 1 Organism: Homo Sapiens
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