+ |
CCN2 | up-regulates
binding
|
LRP6 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178875 |
|
|
Homo sapiens |
|
pmid |
sentence |
18528331 |
Igfbp-4 physically interacted with a wnt receptor, frizzled 8 (frz8), and a wnt co-receptor, low-density lipoprotein receptor-related protein 6 (lrp6), and inhibited the binding of wnt3a to frz8 and lrp6. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NME1 | down-regulates quantity by repression
transcriptional regulation
|
CCN2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255160 |
|
|
Homo sapiens |
|
pmid |
sentence |
17671192 |
To elucidate the molecular mechanism of Nm23-H1 motility suppression, expression microarray analysis of an MDA-MB-435 cancer cell line overexpressing wild-type Nm23-H1 was done and cross-compared with expression profiles from lines expressing the P96S and S120G mutants. Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MZF1 | up-regulates quantity by expression
transcriptional regulation
|
CCN2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-226307 |
|
|
Homo sapiens |
|
pmid |
sentence |
25899830 |
we report the regulation of the CTGF and NOV genes by Myeloid Zinc Finger-1 (MZF-1), a hematopoietic transcription factor. We show the interaction of MZF-1 with the CTGF and NOV promoters in several cell types. Up-regulation of MZF-1 via calcitriol and vitamin A induces expression of CTGF and NOV, implicating a role for these vitamins in the functions of these two genes. Lastly, knockdown of MZF1 reduces levels of CTGF and NOV. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |