Summary

Name EPHA8
Full Name Ephrin type-A receptor 8
Synonyms EPH- and ELK-related kinase, EPH-like kinase 3, EK3, hEK3, Tyrosine-protein kinase receptor EEK | EEK, HEK3, KIAA1459
Primary ID P29322
Links - -
Type protein
Relations 10
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ EPHA8up-regulates activity img/direct-activation.png phosphorylation EPHA8 0.2
Publications: 2 Organism: Homo Sapiens
+ NFIXup-regulates quantity img/direct-activation.png transcriptional regulation EPHA8 0.2
Publications: 1 Organism: Mus Musculus
+ EFNA1up-regulates img/direct-activation.png binding EPHA8 0.811
Publications: 2 Organism: Homo Sapiens
+ NFIAup-regulates quantity img/direct-activation.png transcriptional regulation EPHA8 0.2
Publications: 1 Organism: Mus Musculus
+ EFNA3up-regulates img/direct-activation.png binding EPHA8 0.741
Publications: 1 Organism: Homo Sapiens
+ EFNA5up-regulates img/direct-activation.png binding EPHA8 0.813
Publications: 1 Organism: Homo Sapiens
+ NFIBup-regulates quantity img/direct-activation.png transcriptional regulation EPHA8 0.2
Publications: 1 Organism: Mus Musculus
+ EFNA2up-regulates img/direct-activation.png binding EPHA8 0.741
Publications: 1 Organism: Homo Sapiens