+ |
LTK | down-regulates activity
phosphorylation
|
PREB |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273650 |
Tyr10 |
RRRAPELyRAPFPLY |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
31227593 |
Furthermore, we show that LTK interacts with and phosphorylates Sec12. Expression of a phosphoablating mutant of Sec12 reduces the efficiency of ER export. Thus, LTK-to-Sec12 signaling represents the first example of an ER-resident signaling module with the potential to regulate proteostasis.Altogether, we propose that Sec12 is phosphorylated in a manner dependent on LTK and that this phosphorylation affects ERES function. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LTK | up-regulates
phosphorylation
|
IRS1 |
0.32 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-49531 |
|
|
Homo sapiens |
Neuron |
pmid |
sentence |
9223670 |
Recently, we demonstrated that ltk utilizes shc and irs-1 as two major substrates and while both equally activate the ras pathway, only irs-1 suppresses apoptosis of hematopoietic cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LTK | up-regulates
phosphorylation
|
SHC1 |
0.434 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-49625 |
|
|
Homo sapiens |
Neuron |
pmid |
sentence |
9223670 |
Recently, we demonstrated that ltk utilizes shc and irs-1 as two major substrates and while both equally activate the ras pathway, only irs-1 suppresses apoptosis of hematopoietic cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LTK | up-regulates
binding
|
PIK3CG |
0.256 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-49622 |
|
|
Homo sapiens |
Neuron |
pmid |
sentence |
9223670 |
Although c-cbl is found to be phosphorylated by ltk and therefore is a second candidate linking ltk with the pi3-kinase pathway along with irs-1, we found that the p85 subunit of pi3 kinase directly binds to tyrosine 753 of ltk, which is located within a yxxm motif, a consensus binding amino acid sequence for the sh2 domain of p85 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LTK | up-regulates
phosphorylation
|
CBL |
0.375 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-49528 |
|
|
Homo sapiens |
Neuron |
pmid |
sentence |
9223670 |
Although c-cbl is found to be phosphorylated by ltk and therefore is a second candidate linking ltk with the pi3-kinase pathway along with irs-1, we found that the p85 subunit of pi3 kinase directly binds to tyrosine 753 of ltk, which is located within a yxxm motif, a consensus binding amino acid sequence for the sh2 domain of p85. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |