Summary

Name LTK
Full Name Leukocyte tyrosine kinase receptor
Synonyms Protein tyrosine kinase 1 | TYK1
Primary ID P29376
Links - -
Type protein
Relations 5
Function Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation PREB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CG 0.256
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CBL 0.375
Publications: 1 Organism: Homo Sapiens