Relation Results

Summary

Name LTK
Full Name Leukocyte tyrosine kinase receptor
Synonyms Protein tyrosine kinase 1 | TYK1
Primary ID P29376
Links - -
Type protein
Relations 5
Function Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extra ...
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Type: Score: Layout: SPV 
0.20.3770.4350.2560.319LTKPREBCBLSHC1PIK3CGIRS1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ LTKdown-regulates activity img/direct_inhibition.png phosphorylation PREB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273650 Tyr10 RRRAPELyRAPFPLY Homo sapiens HeLa Cell
pmid sentence
Furthermore, we show that LTK interacts with and phosphorylates Sec12. Expression of a phosphoablating mutant of Sec12 reduces the efficiency of ER export. Thus, LTK-to-Sec12 signaling represents the first example of an ER-resident signaling module with the potential to regulate proteostasis.Altogether, we propose that Sec12 is phosphorylated in a manner dependent on LTK and that this phosphorylation affects ERES function.
Publications: 1 Organism: Homo Sapiens
+ LTKup-regulates img/direct-activation.png phosphorylation CBL 0.377
Identifier Residue Sequence Organism Cell Line
SIGNOR-49528 Homo sapiens Neuron
pmid sentence
Although c-cbl is found to be phosphorylated by ltk and therefore is a second candidate linking ltk with the pi3-kinase pathway along with irs-1, we found that the p85 subunit of pi3 kinase directly binds to tyrosine 753 of ltk, which is located within a yxxm motif, a consensus binding amino acid sequence for the sh2 domain of p85.
Publications: 1 Organism: Homo Sapiens
+ LTKup-regulates img/direct-activation.png phosphorylation SHC1 0.435
Identifier Residue Sequence Organism Cell Line
SIGNOR-49625 Homo sapiens Neuron
pmid sentence
Recently, we demonstrated that ltk utilizes shc and irs-1 as two major substrates and while both equally activate the ras pathway, only irs-1 suppresses apoptosis of hematopoietic cells.
Publications: 1 Organism: Homo Sapiens
+ LTKup-regulates img/direct-activation.png binding PIK3CG 0.256
Identifier Residue Sequence Organism Cell Line
SIGNOR-49622 Homo sapiens Neuron
pmid sentence
Although c-cbl is found to be phosphorylated by ltk and therefore is a second candidate linking ltk with the pi3-kinase pathway along with irs-1, we found that the p85 subunit of pi3 kinase directly binds to tyrosine 753 of ltk, which is located within a yxxm motif, a consensus binding amino acid sequence for the sh2 domain of p85
Publications: 1 Organism: Homo Sapiens
+ LTKup-regulates img/direct-activation.png phosphorylation IRS1 0.319
Identifier Residue Sequence Organism Cell Line
SIGNOR-49531 Homo sapiens Neuron
pmid sentence
Recently, we demonstrated that ltk utilizes shc and irs-1 as two major substrates and while both equally activate the ras pathway, only irs-1 suppresses apoptosis of hematopoietic cells.
Publications: 1 Organism: Homo Sapiens
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