| + |
IL12A | up-regulates quantity by expression 
transcriptional regulation
|
IFNG |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10653850 |
IL-18, originally described as IFN-γ-inducing factor, is secreted from activated macrophages and Kupffer cells (1–3). The major activity associated with this cytokine is induction of IFN-γ production from CD4+ Th1 cells, T cells, B cells and NK cells, especially in collaboration with IL-12 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10653850 |
IL-18, originally described as IFN-γ-inducing factor, is secreted from activated macrophages and Kupffer cells (1–3). The major activity associated with this cytokine is induction of IFN-γ production from CD4+ Th1 cells, T cells, B cells and NK cells, especially in collaboration with IL-12 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
IL12A | up-regulates
|
T_cell_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260966 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10653850 |
IL-12 Synergizes With IL-18 or IL-1beta for IFN-gamma Production From Human T Cells. IL-12 and IL-18 acted in a synergistic manner for the development of T cells into IFN-γ-producing cells without their TCR. Here we show that IL-12 and IL-1beta synergistically induce T cells to proliferate and produce IFN-gamma without their TCR engagement. IL-12 stimulation induced an increase in the proportion of T cells positive for IL-18R engagement. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
IL12A | up-regulates 
binding
|
IL12RB2 |
0.56 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84361 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11086056 |
Il-12r beta 2 plays an essential role in mediating the biological functions of il-12 in mice. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12A | up-regulates
binding
|
IL12B |
0.842 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27619 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7527811 |
However, a proper conformation required for high affinity binding is achieved only when p40 is associated with a p35 subunit or another p40 subunit. When p40 is associated with a p35 subunit, the heterodimer acts as an agonist mediating biologic activity. However, when p40 associates with another p40, the homodimer behaves as an antagonist in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12A | up-regulates
binding
|
IL12RB1 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87677 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12023369 |
Like il-12, il-23 binds to the il-12r subunit il-12rbeta1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
IL12A |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249499 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
3.0
IL12A
- 
- 