+ |
IL23A | up-regulates
binding
|
IL12RB1 |
0.631 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-99716 |
|
|
Homo sapiens |
|
pmid |
sentence |
12671732 |
Based on these analyses, we propose an integrated model of il-12rbeta1 structure and function. This significantly enhances our molecular understanding of the human il-12 and il-23 systems. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-87739 |
|
|
Homo sapiens |
|
pmid |
sentence |
12023369 |
Like il-12, il-23 binds to the il-12r subunit il-12rbeta1. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
IL12A | up-regulates
binding
|
IL12RB1 |
0.553 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-87677 |
|
|
Homo sapiens |
T-lymphocyte |
pmid |
sentence |
12023369 |
Like il-12, il-23 binds to the il-12r subunit il-12rbeta1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IL12B | up-regulates
binding
|
IL12RB1 |
0.663 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-27690 |
|
|
Homo sapiens |
|
pmid |
sentence |
7527811 |
Characterization of the p40 proteins for binding and bioactivity showed that both the p40 monomer and dimer inhibited 125i-labeled il-12 binding to il-12r, but the 80-kda species, having a 50% inhibitory concentration (ic50) of 20 to 70 ng/ml, was at least 20-fold more effective than the monomer. The results suggest that the il-12 p40 subunit contains the essential epitopes for receptor binding. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |