Summary

Name IL12RB1
Full Name Interleukin-12 receptor subunit beta-1
Synonyms IL-12 receptor subunit beta-1, IL-12R subunit beta-1, IL-12R-beta-1, IL-12RB1, IL-12 receptor beta component | IL12R, IL12RB
Primary ID P42701
Links - -
Type protein
Relations 4
Function Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding IL12RB1 0.631
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL12RB1 0.553
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL12RB1 0.663
Publications: 1 Organism: Homo Sapiens