| + |
MAPK14 | up-regulates 
phosphorylation
|
STAT4 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154787 |
Ser721 |
PSDLLPMsPSVYAVL |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates activity
phosphorylation
|
STAT4 |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251425 |
Ser721 |
PSDLLPMsPSVYAVL |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10961885 |
MKK6, phosphorylate STAT4 on serine 721. IL-12 induces STAT4 phosphorylation on serine 721 and that mutation of serine 721 interferes with STAT4 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
JAK2 | up-regulates
phosphorylation
|
STAT4 |
0.672 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142736 |
Tyr693 |
TERGDKGyVPSVFIP |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 16324152 |
Janus family tyrosine kinases jak2 and tyk2, which in turn phosphorylate stat4 on tyrosine 693. The p38 mitogen-activated protein kinase (mapk) signaling pathway is also activated in response to il-12, followed by phosphorylation of stat4 on serine 721, which is required for stat4 full transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TYK2 | up-regulates activity
phosphorylation
|
STAT4 |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279303 |
Tyr693 |
TERGDKGyVPSVFIP |
Homo sapiens |
|
| pmid |
sentence |
| 16324152 |
IL-12 activates the Janus family tyrosine kinases JAK2 and Tyk2, which in turn phosphorylate STAT4 on tyrosine 693. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12A | up-regulates activity
binding
|
STAT4 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280987 |
|
|
Homo sapiens |
Th1 Cell |
| pmid |
sentence |
| 11120802 |
Stat4 activation by IL-12 is required for the function of multiple cytokine pathways that result in IFN-gamma induction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT4 | up-regulates quantity by expression 
transcriptional regulation
|
S100A4 |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255246 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22740693 |
It suggests that HBXIP is able to activate S100A4 promoter via interacting with STAT4 in breast cancer cells, leading to the up-regulation of S100A4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT4 | up-regulates activity
transcriptional regulation
|
IFNG |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280988 |
|
|
Homo sapiens |
Th1 Cell |
| pmid |
sentence |
| 32226303 |
STAT4 increases IFNγ production and Th1 cell differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT4 | up-regulates activity
binding
|
LAMTOR5 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255247 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22740693 |
It suggests that HBXIP is able to activate S100A4 promoter via interacting with STAT4 in breast cancer cells, leading to the up-regulation of S100A4. here we first report that the transcription factor STAT4 plays a role in regulating S100A4 mediated by HBXIP in breast cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL23R | up-regulates
|
STAT4 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87838 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12023369 |
Il-23 activates the same jak-stat signaling molecules as il-12: jak2, tyk2, and stat1, -3, -4, and -5, but stat4 activation is substantially weaker and different dna-binding stat complexes form in response to il-23 compared with il-12. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT4 | up-regulates quantity by expression
transcriptional regulation
|
PRF1 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255245 |
|
|
Homo sapiens |
Natural Killer Cell |
| pmid |
sentence |
| 12372421 |
IL-12-induced expression of the perforin gene in NK cells is directly regulated by STAT4, which binds, most likely as a homo-tetramer, to the tandem STAT-binding sequences in the perforin gene promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
STAT4
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- 