| + |
STAT1 | up-regulates quantity by expression 
transcriptional regulation
|
IL12B |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249500 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12A | up-regulates 
binding
|
IL12B |
0.842 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27619 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7527811 |
However, a proper conformation required for high affinity binding is achieved only when p40 is associated with a p35 subunit or another p40 subunit. When p40 is associated with a p35 subunit, the heterodimer acts as an agonist mediating biologic activity. However, when p40 associates with another p40, the homodimer behaves as an antagonist in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12B | up-regulates
binding
|
IL12RB1 |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7527811 |
Characterization of the p40 proteins for binding and bioactivity showed that both the p40 monomer and dimer inhibited 125i-labeled il-12 binding to il-12r, but the 80-kda species, having a 50% inhibitory concentration (ic50) of 20 to 70 ng/ml, was at least 20-fold more effective than the monomer. The results suggest that the il-12 p40 subunit contains the essential epitopes for receptor binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL12B
- 
- 