| + |
Interleukin-23 receptor-ligand complex | up-regulates activity 
binding
|
JAK2 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280730 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL23R | form complex 
binding
|
Interleukin-23 receptor-ligand complex |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280728 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Interleukin-23 receptor-ligand complex | up-regulates activity
binding
|
STAT3 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280732 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12B | form complex
binding
|
Interleukin-23 receptor-ligand complex |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280726 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL12RB1 | form complex
binding
|
Interleukin-23 receptor-ligand complex |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280727 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL23A | form complex
binding
|
Interleukin-23 receptor-ligand complex |
0.787 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280729 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL23A | up-regulates activity
binding
|
Interleukin-23 receptor-ligand complex |
0.787 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280731 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12023369 |
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12Rbeta1. However, it does not use IL-12Rbeta2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12Rbeta1 to confer IL-23 responsiveness on cells expressing both subunits. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Interleukin-23 receptor-ligand complex
CPX-383