3.0
Summary
| Name |  CCND2View Modifications |
| Full Name | G1/S-specific cyclin-D2 |
| Synonyms | CCND2_HUMAN |
| Primary ID | P30279 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Inhibitors | palbociclib |
| Function | Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ROBO | down-regulates 
phosphorylation
|
CCND2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GSK3B | down-regulates
phosphorylation
|
CCND2 | 0.435 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXL2 | down-regulates quantity by repression 
transcriptional regulation
|
CCND2 | 0.402 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MYCT1 | down-regulates quantity by repression
transcriptional regulation
|
CCND2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | palbociclib | down-regulates
chemical inhibition
|
CCND2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MYC | up-regulates quantity by expression 
transcriptional regulation
|
CCND2 | 0.464 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXL2 | down-regulates quantity by destabilization
binding
|
CCND2 | 0.431 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
CCND2 | 0.428 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | FUBP1 | up-regulates quantity by expression 
transcriptional regulation
|
CCND2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |