| + |
FUBP1 | up-regulates quantity by expression 
transcriptional regulation
|
CDKN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259125 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
In our analysis of FBP1 shRNA-transduced Hep3B cells, we found that p21 mRNA levels increase following FBP1 knockdown, suggesting that FBP1 functions as a repressor of p21. Our results identify the tumor suppressor p21 as the second direct FBP1 target gene in addition to the proto-oncogene c-myc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | down-regulates quantity by repression 
transcriptional regulation
|
TNFSF10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
FBP1 down-regulates cell cycle inhibitors and proapoptotic genes. Interestingly, we also observed the up-regulation of proapoptotic genes following FBP1 knockdown in Hep3B cells. In addition, mRNA levels of the death ligands tumor necrosis factor (TNF) α and tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) were significantly increased. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | down-regulates quantity by repression
transcriptional regulation
|
BIK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259127 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
FBP1 down-regulates cell cycle inhibitors and proapoptotic genes. Interestingly, we also observed the up-regulation of proapoptotic genes following FBP1 knockdown in Hep3B cells. In particular, elevated expression of the Bcl-2 family members Bik and Noxa was detected. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | down-regulates quantity by repression
transcriptional regulation
|
TNF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259130 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
FBP1 down-regulates cell cycle inhibitors and proapoptotic genes. Interestingly, we also observed the up-regulation of proapoptotic genes following FBP1 knockdown in Hep3B cells. In addition, mRNA levels of the death ligands tumor necrosis factor (TNF) α and tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) were significantly increased. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | up-regulates quantity by expression
transcriptional regulation
|
KIT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259132 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30500954 |
Notably, upregulation of c-KIT expression by FUBP1 and RUNX1 promotes cell proliferation and renders cells more resistant to the c-KIT inhibitor imatinib mesylate, a common therapeutic drug. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAL1 | up-regulates quantity by expression 
transcriptional regulation
|
FUBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30653565 |
TAL1 directly activates the FUBP1 promoter, leading to increased FUBP1 expression during erythroid differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | up-regulates quantity by expression
transcriptional regulation
|
CCND2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
A positive cell cycle regulator that we found down-regulated in Hep3B cells upon FBP1 inactivation was cyclin D2. In addition, Cyclin D2 mRNA levels were diminished in the FBP1 knockdown cells, whereas the amount of Cyclin D1 mRNA remained unaffected. Numerous studies have classified D-type cyclins as cell cycle–promoting oncoproteins important for cellular transformation, and our results suggest that cyclin D2 is a candidate FBP1-regulated oncoprotein in HCC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | down-regulates quantity by repression
transcriptional regulation
|
PMAIP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
FBP1 down-regulates cell cycle inhibitors and proapoptotic genes. Interestingly, we also observed the up-regulation of proapoptotic genes following FBP1 knockdown in Hep3B cells. In particular, elevated expression of the Bcl-2 family members Bik and Noxa was detected. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | down-regulates quantity by repression
transcriptional regulation
|
CDKN2B |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259126 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19637194 |
The cell cycle inhibitor p15 was also up-regulated upon FBP1 knockdown. Our analysis of HCC cells after FBP1 knockdown suggests that p15 mRNA levels may also (directly or indirectly) depend on FBP1 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26490982 |
The human far upstream element (FUSE) binding protein 1 (FUBP1) belongs to an ancient family which is required for proper regulation of the c-Myc proto-oncogene. Our results indicated that FUBP1 may potentially stimulate c-Myc expression in ESCC and its expression may promote ESCC progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FUBP1
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