Name	FBXL2 View Modifications
Full Name	F-box/LRR-repeat protein 2
Synonyms	F-box and leucine-rich repeat protein 2, F-box protein FBL2/FBL3 \| FBL2, FBL3
Primary ID	Q9UKC9
Links	- -
Type	protein
Relations	11
Function	Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). {ECO:0000250\|UniProtKB:Q8BH16, ECO:0000269\|PubMed:22020328, ECO:0000269\|PubMed:22323446, ECO:0000269\|PubMed:23604317}.