Summary

Name GCH1
Full Name GTP cyclohydrolase 1
Synonyms GTP cyclohydrolase I, GTP-CH-I | DYT5, GCH
Primary ID P30793
Links - -
Type protein
Relations 19
Function Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding GCH1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown GCH1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown GCH1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GCH1 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown GCH1 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GCH1 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GCH1 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GCH1 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown GCH1 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png stabilization GCH1 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.06
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.04
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Vessel Endothelium
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.05
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.24
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.28
Publications: 1 Organism: Homo Sapiens