| + |
RPS6K | up-regulates activity 
phosphorylation
|
L1CAM |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252766 |
Ser1152 |
RSKGGKYsVKDKEDT |
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 8663493 |
Western blot analysis demonstrated that the L1 kinase activity from PC12 cells that phosphorylated this site was co-eluted with the S6 kinase, p90(rsk). Moreover, S6 kinase activity and p90(rsk) immunoreactivity co-immunoprecipitate with L1 from brain, and metabolic labeling studies have demonstrated that Ser1152 is phosphorylated in vivo in the developing rat brain. | These data demonstrate that the membrane-proximal 15 amino acids of the cytoplasmic domain of L1 are important for neurite outgrowth on L1, and the interactions it mediates may be regulated by phosphorylation of Ser1152. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RPS6KA1 | up-regulates activity
phosphorylation
|
L1CAM |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248948 |
Ser1152 |
RSKGGKYsVKDKEDT |
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 8663493 |
Western blot analysis demonstrated that the L1 kinase activity from PC12 cells that phosphorylated this site was co-eluted with the S6 kinase, p90(rsk). Moreover, S6 kinase activity and p90(rsk) immunoreactivity co-immunoprecipitate with L1 from brain, and metabolic labeling studies have demonstrated that Ser1152 is phosphorylated in vivo in the developing rat brain. | These data demonstrate that the membrane-proximal 15 amino acids of the cytoplasmic domain of L1 are important for neurite outgrowth on L1, and the interactions it mediates may be regulated by phosphorylation of Ser1152. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
RPS6KA2 | up-regulates activity
phosphorylation
|
L1CAM |
0.493 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248949 |
Ser1152 |
RSKGGKYsVKDKEDT |
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 8663493 |
Western blot analysis demonstrated that the L1 kinase activity from PC12 cells that phosphorylated this site was co-eluted with the S6 kinase, p90(rsk). Moreover, S6 kinase activity and p90(rsk) immunoreactivity co-immunoprecipitate with L1 from brain, and metabolic labeling studies have demonstrated that Ser1152 is phosphorylated in vivo in the developing rat brain. | These data demonstrate that the membrane-proximal 15 amino acids of the cytoplasmic domain of L1 are important for neurite outgrowth on L1, and the interactions it mediates may be regulated by phosphorylation of Ser1152. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CSNK2A1 |
phosphorylation
|
L1CAM |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250913 |
Ser1181 |
GEYRSLEsDNEEKAF |
Rattus norvegicus |
Brain |
| pmid |
sentence |
| 8592152 |
Serine to alanine substitutions in these peptides indicate that the CKII phosphorylation site is at Ser1,181. | Finally, in vivo radiolabeling indicates that Ser1,181 is phosphorylated in newborn rat brain. These data show that CKII is associated with and able to phosphorylate L1. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
PRKCA | down-regulates activity 
phosphorylation
|
L1CAM |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276283 |
Thr1172 |
ARPMKDEtFGEYRSL |
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 20335502 |
CKII phosphorylates T1172 of the L1 CD and phosphorylation of T1172 is responsible for loss of 2C2 signal. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NME1 | down-regulates quantity by repression 
transcriptional regulation
|
L1CAM |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255161 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17671192 |
To elucidate the molecular mechanism of Nm23-H1 motility suppression, expression microarray analysis of an MDA-MB-435 cancer cell line overexpressing wild-type Nm23-H1 was done and cross-compared with expression profiles from lines expressing the P96S and S120G mutants. Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
L1CAM
- 
- 