4.0
Summary
| Name |  RPS6KA2View Modifications |
| Full Name | Ribosomal protein S6 kinase alpha-2 |
| Synonyms | S6K-alpha-2, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Ribosomal S6 kinase 3, RSK-3, pp90RSK3 | MAPKAPK1C, RSK3 |
| Primary ID | Q15349 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Inhibitors | 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone |
| Function | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RPS6KA2 | up-regulates activity 
phosphorylation
|
L1CAM | 0.516 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | RPS6KA2 | down-regulates activity 
phosphorylation
|
BAD | 0.372 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KA2 | down-regulates
phosphorylation
|
NFKBIA | 0.267 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KA2 | down-regulates activity
phosphorylation
|
NR4A1 | 0.368 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | RPS6KA2 | down-regulates activity
phosphorylation
|
MRE11 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KA2 | down-regulates
phosphorylation
|
BAD | 0.372 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone | down-regulates activity
chemical inhibition
|
RPS6KA2 | 0.8 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | ERK1/2 | up-regulates
phosphorylation
|
RPS6KA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Gbeta | up-regulates
phosphorylation
|
RPS6KA2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK3 | up-regulates
phosphorylation
|
RPS6KA2 | 0.718 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MTOR | up-regulates activity
phosphorylation
|
RPS6KA2 | 0.393 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | up-regulates
phosphorylation
|
RPS6KA2 | 0.716 |
| Publications: | 1 | Organism: | Homo Sapiens | |