Summary

Name CRHR1
Full Name Corticotropin-releasing factor receptor 1
Synonyms CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1 | CRFR, CRFR1, CRHR
Primary ID P34998
Links - -
Type protein
Relations 18
Function G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GNAI1 0.427
Publications: 1
+ down-regulates img/indirect_inhibition.png CRHR1 0.252
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation POMC 0.642
Publications: 1 Organism: Homo Sapiens
Tissue: Hypophysis
+ down-regulates img/indirect_inhibition.png CRHR1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ down-regulates img/indirect_inhibition.png CRHR1 0.283
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ down-regulates img/indirect_inhibition.png CRHR1 0.277
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Corticotropin 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Hypophysis
+ up-regulates activity img/direct-activation.png binding GNAS 0.465
Publications: 1
+ up-regulates img/direct-activation.png binding CRHR1 0.957
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CRHR1 0.249
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ up-regulates activity img/direct-activation.png binding GNAQ 0.289
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Beta-endorphin 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Hypophysis
+ down-regulates img/indirect_inhibition.png CRHR1 0.251
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ down-regulates img/indirect_inhibition.png CRHR1 0.255
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ down-regulates img/indirect_inhibition.png CRHR1 0.271
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ down-regulates img/indirect_inhibition.png CRHR1 0.265
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ down-regulates img/indirect_inhibition.png CRHR1 0.243
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ down-regulates img/indirect_inhibition.png CRHR1 0.25
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus