Summary

Name ADRA1A
Full Name Alpha-1A adrenergic receptor
Synonyms Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c | ADRA1C
Primary ID P35348
Links - -
Type protein
Relations 20
Inhibitors (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O5-[3-(4,4-diphenyl-1-piperidinyl)propyl] ester O3-methyl ester; phentolamine; silodosin; N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine; prazosin; tamsulosin; terazosin; 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione
Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GNA13 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAS 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAL 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA14 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ADRA1A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition ADRA1A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition ADRA1A 0.14
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation ADRA1A 0.28
Publications: 2 Organism: Cricetulus Griseus, Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation ADRA1A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation ADRA1A 0.22
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation ADRA1A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation ADRA1A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition ADRA1A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition ADRA1A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition ADRA1A 0.08
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition ADRA1A 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ down-regulates img/direct_inhibition.png chemical inhibition ADRA1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAQ 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ADRA1A 0.08
Publications: 1 Organism: Homo Sapiens