Summary

Name PCK1
Full Name Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Synonyms PEPCK-C | PEPCK1
Primary ID P35558
Links - -
Type protein
Relations 19
Pathways Glycolysis and Gluconeogenesis
Function Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:30193097, PubMed:24863970, PubMed:26971250, PubMed:28216384). Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:30193097, PubMed:24863970, PubMed:26971250, PubMed:28216384). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png acetylation PCK1 0.521
Publications: 3 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deacetylation PCK1 0.442
Publications: 3 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation PCK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification phosphonatoenolpyruvate 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png acetylation PCK1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCK1 0.36
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PCK1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification oxaloacetate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ up-regulates quantity img/direct-activation.png transcriptional regulation PCK1 0.401
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PCK1 0.446
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PCK1 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation PCK1 0.372
Publications: 2 Organism: Rattus Norvegicus, Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PCK1 0.2
Publications: 1 Organism: Homo Sapiens