Summary

Name TIMP3
Full Name Metalloproteinase inhibitor 3
Synonyms Protein MIG-5, Tissue inhibitor of metalloproteinases 3, TIMP-3 |
Primary ID P35625
Links - -
Type protein
Relations 5
Pathways FAP: SHH, FAP: IL15
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ TIMP3down-regulates activity img/indirect_inhibition.png Adipogenesis 0.7
Publications: 1 Organism: Mus Musculus
+ TIMP3down-regulates img/indirect_inhibition.png Angiogenesis 0.7
Publications: 1
+ TIMP3down-regulates activity img/direct_inhibition.png binding MMP14 0.591
Publications: 1 Organism: Mus Musculus
+ IL15RAup-regulates img/indirect-activation.png TIMP3 0.2
Publications: 1 Organism: Homo Sapiens
+ SMOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation TIMP3 0.2
Publications: 1 Organism: Mus Musculus