FAP: IL15

Pathway ID: SIGNOR-FICA

Description: IL15 binds its cognate receptor and stimulate FAP proliferation through the JAK/STAT pathway. The same signaling cascade stimulates fibrosis in regenerating muscles that is mediated by myofibrogenic differentiation of FAPs. By contrast, FAP adipogenesis is inhibited via TIMP3.

Curated by: Alessio Reggio

11 Seed Entities

Organism:
Name Primary ID
TYK2 P29597
JAK3 P52333
Proliferation SIGNOR-PH4
PPARG P37231
MMP14 P50281
Adipogenesis SIGNOR-PH26
TIMP3 P35625
IL15 P40933
Fibrosis SIGNOR-PH90
STAT3 P40763
IL15RA Q13261