| + |
IL15RA | up-regulates 
|
TIMP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256232 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Since recent study demonstrated desert Hedgehog (DHH) signaling can repressed FAP-derived adipocyte differentiation through Timp3 [30], we tested the mRNA expression of DHH and Timp3 in injured muscle with injection of IL-15. As expected, mRNA levels of DHH and Timp3 were both upregulated (Fig. 2f). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates quantity by expression
transcriptional regulation
|
TIMP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255907 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 28709001 |
We identified that ciliary Hh signaling in FAPs regulates expression of Timp3. Future experiments will determine whether Timp3 is a direct or indirect target of Hh signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TIMP3 | down-regulates activity 
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255906 |
|
|
Mus musculus |
Muscle Stem Cell |
| pmid |
sentence |
| 28709001 |
Hh signaling through FAP cilia regulated the expression of TIMP3, a secreted metalloproteinase inhibitor, that inhibited MMP14 to block adipogenesis. A pharmacological mimetic of TIMP3 blocked the conversion of FAPs into adipocytes |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TIMP3 | down-regulates
|
Angiogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252274 |
|
|
|
|
| pmid |
sentence |
| 17326328 |
There are many naturally occurring proteins that can inhibit angiogenesis, including angiostatin, endostatin, interferon, platelet factor 4, thorombospondin, prolactin 16 kd fragment, and tissue inhibitor of metalloproteinase-1, -2, and -3 |
|
| Publications: |
1 |
| + |
TIMP3 | down-regulates activity 
binding
|
MMP14 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255908 |
|
|
Mus musculus |
Muscle Stem Cell |
| pmid |
sentence |
| 28709001 |
FAP cilia regulated the expression of TIMP3, a secreted metalloproteinase inhibitor, that inhibited MMP14 to block adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
TIMP3
- 
- 