Relation Results

Summary

Name EIF2S3
Full Name Eukaryotic translation initiation factor 2 subunit 3
Synonyms Eukaryotic translation initiation factor 2 subunit gamma X, eIF-2-gamma X, eIF-2gX | EIF2G
Primary ID P41091
Links - -
Type protein
Relations 6
Function As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternar ...
View More

Viewer

Type: Score: Layout: SPV 
0.7330.6970.6920.7330.940.694EIF2B3EIF2S3EIF2B4EIF2B1EIF2B5Ternary_GTP_eIF2_tRNA_complexEIF2B2

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ EIF2B3up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S3 0.733
Identifier Residue Sequence Organism Cell Line
SIGNOR-269136 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
+ EIF2B4up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S3 0.697
Identifier Residue Sequence Organism Cell Line
SIGNOR-269137 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
+ EIF2B1up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S3 0.692
Identifier Residue Sequence Organism Cell Line
SIGNOR-269134 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
+ EIF2B5up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S3 0.733
Identifier Residue Sequence Organism Cell Line
SIGNOR-269133 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
+ EIF2S3form complex img/form-complex.png binding Ternary_GTP_eIF2_tRNA_complex 0.94
Identifier Residue Sequence Organism Cell Line
SIGNOR-269116 Homo sapiens
pmid sentence
In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2), in a reaction stimulated by factors eIF1, eIF1A and eIF3.
Publications: 1 Organism: Homo Sapiens
+ EIF2B2up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S3 0.694
Identifier Residue Sequence Organism Cell Line
SIGNOR-269135 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
a simple tooltip