| + |
CSNK1A1 |
phosphorylation
|
EIF2B5 |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250787 |
Ser466 |
DEDDGEFsDDSGADQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11500362 |
The fifth site, which lies outside the catalytic domain of eIF2Bepsilon, can be phosphorylated by casein kinase 1. All five sites are phosphorylated in the eIF2B complex in vivo. | A phosphopeptide corresponding to this region was identified in Asp‐N digests of eIF2Bϵ phosphorylated in vitro by CK1, suggesting that Ser461 or Ser464 may be phosphorylated by this kinase in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250788 |
Ser469 |
DGEFSDDsGADQEKD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11500362 |
The fifth site, which lies outside the catalytic domain of eIF2Bepsilon, can be phosphorylated by casein kinase 1. All five sites are phosphorylated in the eIF2B complex in vivo. | A phosphopeptide corresponding to this region was identified in Asp‐N digests of eIF2Bϵ phosphorylated in vitro by CK1, suggesting that Ser461 or Ser464 may be phosphorylated by this kinase in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates activity 
phosphorylation
|
EIF2B5 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251236 |
Ser535 |
ESEQSMDsEEPDSRG |
in vitro |
|
| pmid |
sentence |
| 12133000 |
The largest (epsilon) subunit of eIF2B is a substrate for glycogen synthase kinase (GSK)-3 in vitro, and phosphorylation by GSK3 inhibits the activity of eIF2B. The site of phosphorylation has previously been identified as Ser(535). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251237 |
Ser540 |
MDSEEPDsRGGSPQM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11500362 |
We identify multiple phosphorylation sites in the largest, catalytic, subunit (epsilon) of mammalian eIF2B. Glycogen synthase kinase 3 (GSK3) is responsible for phosphorylating Ser535. This regulatory phosphorylation event requires both the fourth site (Ser539) and a distal region, which acts to recruit GSK3 to eIF2Bepsilon in vivo. eIF2Bϵ from mammals or insects is a substrate for glycogen synthase kinase 3 (GSK3), and this inhibits the activity of eIF2B |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
GSK3B | down-regulates
phosphorylation, binding
|
EIF2B5 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180022 |
Ser540 |
MDSEEPDsRGGSPQM |
Homo sapiens |
|
| pmid |
sentence |
| 18701453 |
Gsk3_ phosphorylates eif2b_ at ser-539 (ser-535 in the rat sequence) and inactivates it |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175621 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Akt also promotes protein synthesis by phosphorylating and inactivating gsk3b, thus releasing the gsk3b-dependent inhibition of the eukariotic translation initiation factor 2b (eif2b). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GSK3A | down-regulates activity
phosphorylation
|
EIF2B5 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251215 |
Ser540 |
MDSEEPDsRGGSPQM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11500362 |
We identify multiple phosphorylation sites in the largest, catalytic, subunit (epsilon) of mammalian eIF2B. Glycogen synthase kinase 3 (GSK3) is responsible for phosphorylating Ser535. This regulatory phosphorylation event requires both the fourth site (Ser539) and a distal region, which acts to recruit GSK3 to eIF2Bepsilon in vivo. eIF2Bϵ from mammals or insects is a substrate for glycogen synthase kinase 3 (GSK3), and this inhibits the activity of eIF2B |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A2 | up-regulates activity 
phosphorylation
|
EIF2B5 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250989 |
Ser717 |
LKEAEEEsSEDD |
Homo sapiens |
|
| pmid |
sentence |
| 11500362 |
Two conserved sites (Ser712/713) are phosphorylated by casein kinase 2. They lie at the extreme C-terminus and are required for the interaction of eIF2Bepsilon with its substrate, eIF2, in vivo and for eIF2B activity in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250990 |
Ser718 |
KEAEEESsEDD |
Homo sapiens |
|
| pmid |
sentence |
| 11500362 |
Two conserved sites (Ser712/713) are phosphorylated by casein kinase 2. They lie at the extreme C-terminus and are required for the interaction of eIF2Bepsilon with its substrate, eIF2, in vivo and for eIF2B activity in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
EIF2B5 |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250859 |
Ser717 |
LKEAEEEsSEDD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11500362 |
Two conserved sites (Ser712/713) are phosphorylated by casein kinase 2. They lie at the extreme C-terminus and are required for the interaction of eIF2Bepsilon with its substrate, eIF2, in vivo and for eIF2B activity in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250860 |
Ser718 |
KEAEEESsEDD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11500362 |
Two conserved sites (Ser712/713) are phosphorylated by casein kinase 2. They lie at the extreme C-terminus and are required for the interaction of eIF2Bepsilon with its substrate, eIF2, in vivo and for eIF2B activity in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
EIF2B5 | up-regulates activity
guanine nucleotide exchange factor
|
Ternary_GTP_eIF2_tRNA_complex |
0.81 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2B5 | up-regulates activity
guanine nucleotide exchange factor
|
EIF2S2 |
0.873 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FRAT1 | up-regulates activity
binding
|
EIF2B5 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262835 |
|
|
|
|
| pmid |
sentence |
| 10481074 |
In contrast to the GS‐1 peptide, glycogen synthase and the eIF2B peptide, the GSK3‐catalysed phosphorylation of Tau was completely inhibited by FRATtide|This prevents GSK3 from phosphorylating and inhibiting glycogen synthase [2, 3] and protein synthesis initiation factor eIF2B |
|
| Publications: |
1 |
| + |
EIF2B5 | up-regulates activity
guanine nucleotide exchange factor
|
EIF2S3 |
0.724 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269133 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2B5 | up-regulates activity
guanine nucleotide exchange factor
|
EIF2S1 |
0.834 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EIF2B5
- 
- 