Summary

Name GRIA2
Full Name Glutamate receptor 2
Synonyms GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 | GLUR2
Primary ID P42262
Links - -
Type protein
Relations 11
Pathways Rett syndrome
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation GRIA2 0.697
Publications: 3 Organism: In Vitro, Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding GRIA2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization GRIA2 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation GRIA2 0.333
Publications: 1 Organism: Rattus Norvegicus
Pathways:Rett syndrome
+ up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation GRIA2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Publications: 1 Organism: In Vitro
Pathways:Rett syndrome
+ up-regulates activity img/direct-activation.png binding GRIA2 0.801
Publications: 1 Organism: Chlorocebus Aethiops