4.0
Summary
| Name |  RUNX3View Modifications |
| Full Name | Runt-related transcription factor 3 |
| Synonyms | Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3, CBF-alpha-3, Oncogene AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit, PEA2-alpha C, PEBP2-alpha C, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit | AML2, CBFA3, PEBP2A3 |
| Primary ID | Q13761 |
| Links |  -  -  |
| Type | protein |
| Relations | 21 |
| Function | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MDM2 | down-regulates quantity by destabilization 
ubiquitination
|
RUNX3 | 0.595 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK4 | down-regulates
phosphorylation
|
RUNX3 | 0.394 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CyclinD/CDK4 | down-regulates
phosphorylation
|
RUNX3 | 0.534 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates quantity by repression 
transcriptional regulation
|
PEA15 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | up-regulates quantity by expression 
transcriptional regulation
|
CASP2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates quantity by repression
transcriptional regulation
|
HSPD1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates quantity by repression
transcriptional regulation
|
CFLAR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | up-regulates quantity by expression
transcriptional regulation
|
TRAF6 | 0.248 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | up-regulates quantity by expression
transcriptional regulation
|
DNASE1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | up-regulates quantity by expression
transcriptional regulation
|
CAPN10 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates quantity by repression
transcriptional regulation
|
IKBKB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates
binding
|
NOTCH1 | 0.703 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | up-regulates quantity by expression
transcriptional regulation
|
ING4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | up-regulates quantity by expression
transcriptional regulation
|
ING1 | 0.247 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | up-regulates quantity by expression
transcriptional regulation
|
ELANE | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIM1 | up-regulates quantity 
phosphorylation
|
RUNX3 | 0.349 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC | down-regulates activity
phosphorylation
|
RUNX3 | 0.599 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates quantity by repression
transcriptional regulation
|
TIAL1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates quantity by repression
transcriptional regulation
|
CHUK | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | up-regulates quantity by expression
transcriptional regulation
|
FADD | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates quantity by repression
transcriptional regulation
|
TXN2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |