Relation Results

Summary

Name IL23A
Full Name Interleukin-23 subunit alpha
Synonyms IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19 | SGRF
Primary ID Q9NPF7
Links - -
Type protein
Relations 5
Function Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute wi ...
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Type: Score: Layout: SPV 
0.6360.8580.20.2IL23AIL12RB1IL23RSATB1CEBPD

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Relations
Regulator
Mechanism
target
score ℹ
+ IL23Aup-regulates img/direct-activation.png binding IL12RB1 0.636
Identifier Residue Sequence Organism Cell Line
SIGNOR-87739 Homo sapiens
pmid sentence
Like il-12, il-23 binds to the il-12r subunit il-12rbeta1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-99716 Homo sapiens
pmid sentence
Based on these analyses, we propose an integrated model of il-12rbeta1 structure and function. This significantly enhances our molecular understanding of the human il-12 and il-23 systems.
Publications: 2 Organism: Homo Sapiens
+ IL23Aup-regulates img/direct-activation.png binding IL23R 0.858
Identifier Residue Sequence Organism Cell Line
SIGNOR-87805 Homo sapiens T-lymphocyte
pmid sentence
We identify a novel member of the hemopoietin receptor family as a subunit of the receptor for il-23, il-23r.
Publications: 1 Organism: Homo Sapiens
+ SATB1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL23A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255132 Homo sapiens K-562 Cell
pmid sentence
We found 59 up-regulated and 75 down-regulated genes in the K562-SATB1 cells that were not observed in the K562 cells. Partial genes that have special biological functions are listed in Table 1.
Publications: 1 Organism: Homo Sapiens
+ CEBPDup-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL23A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254061 Mus musculus Macrophage
pmid sentence
CEBPD activated in macrophages played a functional role in promoting the tube formation of endothelial cells and the migration and proliferation of synoviocytes. In vivo DNA binding assays and reporter assays showed that CEBPD up-regulated CCL20, CXCL1, IL23A and TNFAIP6 transcripts through direct binding to their promoter regions.
Publications: 1 Organism: Mus Musculus
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