| + |
CXCL5 | up-regulates activity 
binding
|
CXCR2 |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277730 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 38339310 |
CXCL5 is another ELR+ CXC chemokine and, thus, also potently attracts neutrophils. Just like CXCL1, CXCL5 also signals through CXCR2, explaining why, often, CXCL5 and CXCL1 are seen to function in parallel in PDAC. CXCL5 was increased in human pancreatic tissue compared to the normal pancreas, and the knockdown of CXCL5 in pancreatic cancer cell lines reduced the proliferation and migration ability of cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DDR1 | up-regulates quantity by expression 
transcriptional regulation
|
CXCL5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277731 |
|
|
Homo sapiens |
MDA-Panc-28 Cell |
| pmid |
sentence |
| 34237033 |
We demonstrate that collagen-induced DDR1 activation in cancer cells is a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils (TANs), the formation of neutrophil extracellular traps (NETs), and subsequent cancer cell invasion and metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL5 | up-regulates
|
Neutrophil_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277732 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 34237033 |
We demonstrate that collagen-induced DDR1 activation in cancer cells is a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils (TANs), the formation of neutrophil extracellular traps (NETs), and subsequent cancer cell invasion and metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL5 | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277733 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 34237033 |
We demonstrate that collagen-induced DDR1 activation in cancer cells is a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils (TANs), the formation of neutrophil extracellular traps (NETs), and subsequent cancer cell invasion and metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CXCL5
- 
- 